Publications by authors named "F Gagliardi"
several experimental findings and epidemiological observations indicated that aspirin/acetylsalicylic acid (ASA) may be endowed with anticancer effects against a variety of human malignancies, including thyroid carcinomas. Among these, undifferentiated/anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal human cancers, refractory to all currently available therapies. we here evaluated in a preclinical setting the effects of ASA on a panel of three ATC-derived cell lines: the CAL-62, the 8305C, and the 8505C.
View Article and Find Full Text PDFLatin American countries are distinguished by their highly admixed populations, characterized by a significant preservation of Native American matrilineal ancestry. This contrasts with the paternal lineages, which exhibit different patterns due to pronounced sex-biased mating practices during the colonial period. Uniparental genetic markers have been instrumental in population genetics, facilitating the reconstruction of human settlement histories and serving forensic identification purposes.
View Article and Find Full Text PDFGlioblastoma (GBM) is the most common, fast-growing, and aggressive malignant primary CNS tumor, with a survival time of ~15 months despite the use of surgery and adjuvant treatments. In recent years, there has been a growing interest in exploring the potential contribution of hemostasis and platelet activation in GBM biology. The present study assessed the association between the pre-operative coagulation profile [as indicated by prothrombin time (PT) ratio and activated partial thromboplastin time (aPTT) ratio], overall platelets (PLT) count and the mean platelet volume (MPV) with tumoral characteristics and overall survival in patients with isocitrate dehydrogenase-wildtype (IDH-wt) GBM.
View Article and Find Full Text PDFArticle Synopsis
- This study looked at the safety and effectiveness of a treatment called Gamma-knife stereotactic radiosurgery (SRS-GK) for a type of brain tumor called radiation-induced meningiomas (RIMs) at a hospital in Italy.
- They included data from 13 patients and found that 26% improved, while 52% stayed the same and 22% got worse, with a good control rate over 5 years.
- In a bigger analysis, including 146 patients, the overall success rate was high, but some patients experienced side effects like swelling, showing that while SRS-GK works well, there can be risks involved.
Article Synopsis
- This review examines the importance of radiotherapy in cancer treatment and how genetic profiling can enhance its effectiveness.
- It identifies genetic markers that help predict how patients might react to radiation, allowing for more personalized treatment plans.
- The findings suggest that integrating genetic profiling can improve treatment responses and outcomes, supporting the shift towards precision medicine in oncology.