R2R01: A long-acting single-chain peptide agonist of RXFP1 for renal and cardiovascular diseases.

Background: The therapeutic potential of relaxin for heart failure and renal disease in clinical trials is hampered by the short half-life of serelaxin. Optimization of fatty acid-acetylated single-chain peptide analogues of relaxin culminated in the design and synthesis of R2R01, a potent and selective RXFP1 agonist with subcutaneous bioavailability and extended half-life.

Experimental Approach: Cellular assays and pharmacological models of RXFP1 activation were used to validate the potency and selectivity of R2R01.

A G-protein-biased S1P1 agonist, SAR247799, improved LVH and diastolic function in a rat model of metabolic syndrome.

Aim: Heart failure with preserved ejection fraction (HFpEF) is a major cause of death worldwide with no approved treatment. Left ventricular hypertrophy (LVH) and diastolic dysfunction represent the structural and functional components of HFpEF, respectively. Endothelial dysfunction is prevalent in HFpEF and predicts cardiovascular events.

Capacitive Pressure Sensor with Wide-Range, Bendable, and High Sensitivity Based on the Bionic Komochi Konbu Structure and Cu/Ni Nanofiber Network.

High-performance flexible pressure sensors have an essential application in many fields such as human detection and human-computer interaction. Herein, on the basis of the dielectric layer of a bionic komochi konbu structure, we propose a low-cost and novel capacitive sensor that achieves high sensitivity and stability over a broad range of tactile pressures. Further, the flexible and durable electrode layer of the transparent junctionless copper/nickel-nanonetwork was prepared based on electrospinning and electroless deposition techniques, which ensured high bending stability and high cycle stability of our sensor.

Dataset of vibrational and acoustic measurements for squeal analysis from the laboratory brake setup Friction-Induced Vibration and noisE at Ecole Centrale de Lyon (FIVE@ECL).

This data article comprises raw records to investigate the dynamic behavior of a brake system during controlled braking tests and its squeal characterization through the generation of friction-induced vibration. Experiments have been performed on the laboratory brake setup Friction-Induced Vibration and noisE at Ecole Centrale de Lyon (FIVE@ECL), France. The data provided include measurements for each component of the brake system (i.