Publications by authors named "F G Garaci"
Article Synopsis
- - The study investigates the reliability of Diffusion Kurtosis Imaging (DKI) parameters by comparing them with perfusion metrics from Dynamic Contrast Enhanced (DCE) and Dynamic Susceptibility Contrast (DSC) MRI techniques in primary central nervous system lymphoma (PCNSL) patients.
- - Analysis of 15 lesions from patients with Epstein-Barr Virus negative PCNSL showed significant correlations, notably between DKI parameters and both DCE/DSC metrics, suggesting that DKI adds valuable insights beyond traditional diffusion models.
- - The findings indicate a strong inverse correlation between several DKI parameters and perfusion metrics, pointing to DKI's potential to enhance understanding of tumor characteristics and inform clinical practices.
Article Synopsis
- The study aimed to investigate the relationship between CT measurements of fat, body mass index (BMI), and the role of sarcopenia in early and long-term complications following transcatheter aortic valve implantation (TAVI).
- Researchers analyzed data from 85 patients, finding significant positive correlations between fat measurements and BMI, as well as a negative relation between fat density and quantity.
- The results confirmed the 'obesity paradox,' indicating that being overweight or obese can be beneficial for TAVI outcomes, while sarcopenia is linked to poorer prognosis, highlighting the potential of using CT for better patient outcome predictions.
In recent years, prostate-specific membrane antigen (PSMA), a transmembrane glycoprotein, has emerged as a promising biomarker for theranostics, integrating diagnosis and therapy. PSMA's overexpression in various tumors, including brain metastases and high-grade gliomas, suggests its potential in neuro-oncology. Pruis et al.
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- The study evaluated the effectiveness of MRI sequences (T1-TSE, T2-TSE, and 3D FLAIR) with and without the Compressed-SENSE technique by measuring contrast, contrast-to-noise ratio (CNR), and signal-to-noise ratio (SNR).
- A total of 142 MRI images were analyzed, with regions of interest marked by radiologists to assess differences in CNS structures (white matter, grey matter, cerebrospinal fluid).
- Results showed that while Compressed-SENSE improved image quality in specific T1-TSE sequences, it had mixed effects on contrast values in other sequences, ultimately demonstrating its potential for faster MRI scans without compromising essential diagnostic information.
Objectives: Despite successful recanalization after Mechanical Thrombectomy (MT), approximately 25 % of patients with Acute Ischemic Stroke (AIS) due to Large Vessel Occlusion (LVO) show unfavorable clinical outcomes, namely Futile Recanalization (FR). We aimed to use a Machine Learning (ML) Non-Contrast brain CT (NCCT) imaging predictive model to identify FR in patients undergoing MT.
Materials & Methods: Between July 2022 and December 2022, 70 consecutive patients with LVO undergoing a complete recanalization (eTICI 3) with MT within 8 h from onset at our Centre were analyzed.