Shaping Ability of XP-Endo Shaper Files with Extended Use Time and Reciproc Blue 40.06 in Oval Canals: A Micro-Computed Tomography Study in Contralateral Premolars.

Introduction: This study evaluated the shaping ability of the single-file XP-endo Shaper (XP-S) system, employing an extended working time, and the Reciproc Blue #40/.06 (REC) instrument during the preparation of oval-shaped canals.

Methods: Eleven pairs of contralateral premolars with a single canal were divided into two groups (n = 11) according to the canal preparation protocol: XP-S (with an additional 45 seconds of instrumentation) and REC.

Total neoadjuvant therapy followed by total mesorectal excision for rectal cancer in older patients real world data and proof of concept.

Background: Rectal cancer (RC) commonly affects older patients. Total Neoadjuvant Therapy (TNT) has been introduced to improve local and systemic control of RC. The aim was to present real-world data of older patients receiving TNT followed by surgery after a frailty assessment and verify feasibility and safety of this approach.

Cryo-EM structure of a novel α-synuclein filament subtype from multiple system atrophy.

Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by accumulation of α-synuclein cross-β amyloid filaments in the brain. Previous structural studies of these filaments by cryo-electron microscopy (cryo-EM) revealed three discrete folds distinct from α-synuclein filaments associated with other neurodegenerative diseases. Here, we use cryo-EM to identify a novel, low-populated MSA filament subtype (designated Type I) in addition to a predominant class comprising MSA Type II filaments.