Publications by authors named "F Fujisawa"
Article Synopsis
- Radiation-induced angiosarcoma is a highly aggressive cancer that can arise after treatment for other malignancies, such as breast cancer.
- In this case, the patient developed angiosarcoma in both breasts seven years after undergoing a partial mastectomy and radiation therapy.
- After surgical intervention, chemotherapy was halted due to severe complications, and unfortunately, the cancer recurred and progressed rapidly, leading to the patient's death within two months.
Article Synopsis
- Comprehensive genome profiling (CGP) has changed healthcare by paving the way for personalized medicine, but its real-world effectiveness is still uncertain.
- A study at the Osaka International Cancer Institute analyzed data from 1,096 advanced solid tumor patients to assess how often CGP led to suitable therapies and its impact on patient outcomes.
- The findings revealed that while CGP provided clinical trial options for 60.9% of patients, only a small fraction (1.1%) could enroll, and the progression-free survival for treatments was generally short, indicating a need for better integration of CGP into trial systems and patient care.
Article Synopsis
- The study investigated the detection of gBRCA mutations in pancreatic cancer patients and the effectiveness of olaparib maintenance therapy for those mutations.
- Out of 84 patients tested, 11.9% had gBRCA mutations, with a higher mutation rate found in individuals with a family history of Hereditary Breast and Ovarian Cancer (HBOC).
- Most patients who received olaparib after platinum-based chemotherapy showed positive responses, with a median treatment duration of 17.5 months for chemotherapy and 11 months for olaparib maintenance therapy.
Background: Patients with familial adenomatous polyposis (FAP) have a lifetime risk of developing duodenal adenomas approaching 100%, and the relative risk for duodenal cancer compared with the general population is high. We conducted a retrospective study to investigate the progression of non-ampullary duodenal adenomas (NADAs) and risk factors for advanced lesions in patients with FAP.
Methods: Of 248 patients with 139 pedigrees at 2 institutes, we assessed 151 patients with 100 pedigrees with a pathogenic germline variant in the adenomatous polyposis coli gene, excluding mosaic variants.
Brain metastases develop in 0.5-0.7% of patients with gastric/gastroesophageal junction (G/GEJ) cancer.
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