Publications by authors named "F Frongillo"
Article Synopsis
- The study analyzes how effective liver resection (LR) and liver transplantation (LT) are in treating hepatocellular carcinoma (HCC) by comparing multiple previous studies.
- Findings show that LT offers better 5-year overall survival and disease-free survival rates compared to LR for HCC patients.
- It concludes that while LT is generally superior, in cases of recurrence, LR can still be a viable option given the shortage of available organs for transplantation.
Cholangiopathies include a group of chronic progressive disorders, affecting the cholangiocytes, the epithelial cells that line the biliary tree, leading to liver parenchymal fibrosis and eventually end-stage liver disease necessitating transplantation. Experimental modeling of these multifactorial cholestatic diseases faces challenges due to the lack of adequate experimental in vitro and in vivo models. A novel approach employs three-dimensional organoid systems that offer several advantages for modeling disease and testing drug response in vitro.
View Article and Find Full Text PDF: The role of tailored immunosuppression (IS) in the development of the humoral response (HR) to SARS-CoV-2 mRNA-based vaccination in liver transplant (LT) recipients is unknown. : This is a single-centre prospective study of patients who underwent LT between January 2015 and December 2021 and who have received three doses of mRNA-based SARS-CoV-2 vaccination. Patients undergoing Tacrolimus-based immunosuppression (TAC-IS) were compared with those undergoing Everolimus-based immunosuppression (EVR-IS).
View Article and Find Full Text PDFIncreasing organ shortage results in extended criteria donors (ECD) being used to face the growing demand for liver grafts. The demographic change leads to greater use of elderly donors for liver transplantation, historically considered marginal donors. Age is still considered amongst ECD in liver transplantation as it could affect transplant outcomes.
View Article and Find Full Text PDFArticle Synopsis
- Cholangiocarcinoma (CCA) includes malignant tumors from the bile duct's epithelial cells, with about 40% classified as perihilar cholangiocarcinoma (pCCA), which often can't be surgically removed at diagnosis.
- Liver transplantation (LT) is a viable alternative for unresectable pCCA, offering a 1-year survival rate of 91% and a 5-year rate of 73%, though success varies by underlying conditions.
- The limited availability of organs complicates the preference for LT as a treatment, and while options like living donor transplants exist, there's ongoing debate on whether surgical resection or LT should be the standard treatment.