Publications by authors named "F Froehlich"
Introduction: Colorectal cancer (CRC) screening relies primarily on colonoscopy and fecal immunochemical testing (FIT). Aligning utilization of these options with individual CRC risk may optimize benefit with lower risks, individual burden, and societal costs. We studied the effect of communicating personalized CRC risk and corresponding screening recommendations on risk-appropriate screening uptake in an organized screening setting.
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- Immune checkpoint inhibitors (ICIs) are a key treatment for melanoma but can cause pancreatic injury, which is not well-studied or managed.* -
- A study involving 1516 melanoma patients found that 204 experienced elevated lipase levels, with many showing symptoms of pancreatitis, leading to treatment interruptions for nearly half of them.* -
- Despite the lack of guidelines recommending routine lipase monitoring, it was performed in the study, revealing higher-than-expected rates of elevation, particularly in symptomatic patients.*
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- Pregnancy is interesting because the baby and placenta can stay inside the mother without being rejected by her immune system.
- A part of this immune system, called the complement system, needs to be carefully managed during pregnancy to avoid problems like pre-eclampsia and slow growth of the baby.
- The study found that a specific part of this system, called C5aR2, is important for helping certain immune cells in the uterus, known as NK cells, work correctly for a healthy pregnancy.
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- - The study examined the effects of the 2019 BMJ recommendation against colorectal cancer (CRC) screening for adults with less than a 3% risk over 15 years, using Switzerland's population data.
- - It found that following this guideline would significantly delay screening for most individuals (ages 65 for women and 60 for men) and reduce the number of tests needed by 43%-57%, but also lead to fewer CRC deaths prevented and fewer life-years gained.
- - The conclusion suggested that the 3% risk threshold for initiating screening may be too high, as the impact of this recommendation would closely resemble standard age- and sex-based screening approaches, delaying care by 10-15 years.
Nutritional support in malnourished animals is an essential aspect of wildlife rehabilitation; this support is especially relevant when providing lifesaving nutrition to endangered species such as the African penguin (). This study investigated the short-term effects of a commercially available, semi-elemental, critical care diet compared with a hand-made fish formula. Twenty-one African penguin chicks were selected on admission to the Southern African Foundation for the Conservation of Costal Birds in Cape Town, South Africa, in November 2015.
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