Publications by authors named "F Forini"
Article Synopsis
- - The study explored how inositol (INO) supplementation affects heart changes in mice caused by lithium (Li) exposure, using four different mouse groups over a 12-week period.
- - Findings showed that INO supplementation significantly reduced heart-related issues caused by Li, such as heart function impairment and arrhythmias, possibly by restoring potassium channel expression and inhibiting certain signaling pathways.
- - INO was effective both as a preventive measure when given with Li and as a therapeutic treatment when given after heart damage had occurred, highlighting its potential as a treatment for Li-induced heart problems.
Thyroid Hormones (THs) play a central role in the development, cell growth, differentiation, and metabolic homeostasis of neurosensory systems, including the retina. The coordinated activity of various components of TH signaling, such as TH receptors (THRs) and the TH processing enzymes deiodinases 2 and 3 (DIO2, DIO3), is required for proper retinal maturation and function of the adult photoreceptors, Müller glial cells, and pigmented epithelial cells. Alterations of TH homeostasis, as observed both in frank or subclinical thyroid disorders, have been associated with sight-threatening diseases leading to irreversible vision loss i.
View Article and Find Full Text PDFBackground: Sacubitril/valsartan has been demonstrated to promote left ventricular (LV) reverse remodelling and improve outcomes in patients with heart failure (HF) with reduced ejection fraction (EF). Its molecular and tissue effects have not been fully elucidated yet, due to the paucity of preclinical studies, mostly based on ischaemic models. We aimed to evaluate the effects of sacubitril/valsartan on LV remodelling, myocardial fibrosis and mitochondrial biology in a murine model of non-ischaemic LV dysfunction.
View Article and Find Full Text PDF