Publications by authors named "F Forbici"
Article Synopsis
- Enteroviruses (EVs) are common worldwide pathogens, primarily impacting children and causing a range of illnesses, including aseptic meningitis, but their true prevalence and epidemiology remain poorly understood.
- Research focused on the Lazio region over a decade revealed changes in EV infection trends, particularly influenced by the SARS-CoV-2 pandemic, with a return to pre-pandemic circulation patterns by 2022 but with shifts in dominant strains identified.
- Ongoing studies are essential to understand the pathogenic potential of prevalent strains and to identify any new recombinant variants.
Article Synopsis
- The study analyzed HIV-1 sequences from 2386 drug-naïve individuals in Italy from 2015 to 2021 to assess the prevalence of transmitted drug resistance (TDR) among them.
- TDR prevalence was found to be 8%, with a slight difference between B subtypes (9.5%) and non-B subtypes (6.1%), and it remained stable over the years assessed.
- The research indicated that certain subtypes were associated with lower TDR rates, emphasizing the need for ongoing monitoring of TDR in newly diagnosed HIV patients to improve treatment strategies.
In a restricted subset of people living with HIV-1 (PLWH) on antiretroviral therapy (ART) with persistent suppressed viral load (i.e., -based HIV-RNA repeatedly undetected), a dual-target ( and ) diagnostic assay for HIV-RNA monitoring can measure quantifiable levels of viral loads (VL) above 30 copies/mL exclusively through the amplification of the region, while the target results undetected.
View Article and Find Full Text PDFBackground: A rapid ART initiation approach can be beneficial in people with advanced HIV disease, in consideration of their high morbidity and mortality. The aim of our study was to evaluate the feasibility, efficacy and safety of rapid ART start with BIC/FTC/TAF in this setting.
Methods: Pilot, single-centre, single-arm, prospective, phase IV clinical trial conducted in a tertiary Italian hospital.