Publications by authors named "F Fleury"
Photonic crystals (PCs) are promising tools for label-free sensing in drug discovery screening, diagnostics, and analysis of ligand-receptor interactions. Imaging of PC surface modes has emerged as a novel approach to the detection of multiple binding events at the sensor surface. PC surface modification and decoration with recognition units yield an interface providing the highly sensitive detection of cancer biomarkers, antibodies, and oligonucleotides.
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- The study aimed to analyze various theories, models, and frameworks (TMFs) that organizations use to evaluate knowledge mobilization (KMb) strategies, addressing the confusion arising from their multitude.
- A scoping review was conducted, examining 88 articles out of 4,763 search results, primarily focusing on KMb strategies in health, published post-2010, with most originating from Canada, Australia, the U.S., and the U.K.
- Findings revealed that process models and evaluation frameworks were the most frequently used TMFs for KMb evaluations, with a significant emphasis on training and educating stakeholders as key activities in the evaluation process.
RAD51 is a pivotal protein of the homologous recombination DNA repair pathway, and is overexpressed in some cancer cells, disrupting then the efficiency of cancer-treatments. The development of RAD51 inhibitors appears as a promising solution to restore these cancer cells sensitization to radio- or chemotherapy. From a small molecule identified as a modulator of RAD51, the 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS), two series of analogues with small or bulky substituents on the aromatic parts of the stilbene moiety were prepared for a structure-activity relationship study.
View Article and Find Full Text PDFHigh-throughput protein assays are crucial for modern diagnostics, drug discovery, proteomics, and other fields of biology and medicine. It allows simultaneous detection of hundreds of analytes and miniaturization of both fabrication and analytical procedures. Photonic crystal surface mode (PC SM) imaging is an effective alternative to surface plasmon resonance (SPR) imaging used in conventional gold-coated, label-free biosensors.
View Article and Find Full Text PDFThe role of intestinal bacterial microbiota has been described as key in the pathophysiology of Crohn's disease (CD). CD is characterized by frequent relapses after periods of remission which are not entirely understood. In this paper, we investigate whether the heterogeneity in microbiota profiles in CD patients could be a suitable predictor for these relapses.
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