Publications by authors named "F Ficara"
Article Synopsis
- * In research using a mouse model that mimics ARO, gene therapy (GT) with lentiviral vectors effectively improved bone density and allowed for long-term survival, while also enhancing the collection of necessary stem cells through a method called plerixafor-induced mobilization.
- * The study suggests that non-genotoxic conditioning before transplantation can lead to better outcomes, including stable stem cell engraftment and improved bone health, providing a
RANKL and its cognate receptor RANK are crucial regulators of bone metabolism in physiological as well as in pathological conditions. Here we go through the works that unveiled the paramount role of this signaling pathway. We focus on the RANKL cytokine, whose alterations are responsible for rare and common bone diseases.
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- Skeletal Stem Cells (SSCs) are crucial for bone development and repair, and the cytokine RANKL plays an important role in their regulation, making it a key focus for research in regenerative medicine.
- In experiments with mice lacking RANKL, researchers found that SSCs had a higher frequency but showed impaired ability to differentiate into bone-forming cells, indicating the significance of RANKL in SSC functionality.
- Additionally, treating human bone marrow-derived stromal cells with the anti-RANKL antibody Denosumab resulted in decreased osteogenic potential, highlighting the potential impact of RANKL modulation on bone health.
Pre-B cell leukemia factor 1 (PBX1) is a Three Aminoacid Loop Extension (TALE) homeodomain-containing transcription factor playing crucial roles in organ pattering during embryogenesis, through the formation of nuclear complexes with other TALE class and/or homeobox proteins to regulate target genes. Its contribution to the development of several organs has been elucidated mainly through the study of murine knockout models. A crucial role for human development has been recently highlighted through the discovery of different pathogenic PBX1 variants in children affected by developmental defects.
View Article and Find Full Text PDFUnderstanding disasters as socially constructed events represents a departure from current and historic ways in which disasters are characterized, requiring a focal shift in thinking from forces of nature toward social order. Changing societal reactions to evolving natural occurrences restores disasters within the social order, introducing law as an essential framework in approaching disasters as injustices as opposed to misfortunes. International attention is starting to shift strategies intended to reduce risks to natural or man-made hazards and increasing attention on methods toward minimizing their impact known as disaster risk reduction (DRR).
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