Publications by authors named "F Ferrau'"
Dyslipidemia is a potential unfavorable prognostic factor in neuroendocrine tumors (NETs); conversely, statins proved to have antiproliferative effects in NET cell lines and could be a helpful therapeutic strategy for these patients. The main objective of this observational cohort retrospective study is to explore the associations between dyslipidemia and NET progression and evaluate the potential influence of statins in this context. 393 patients with histologically confirmed gastroenteropancreatic or bronchopulmonary NETs from six Italian centres didicated to NET diagnosis and therapy were included.
View Article and Find Full Text PDFArticle Synopsis
- The research investigates the psychological impacts of acromegaly, a rare condition that can lead to anxiety and depression among patients.
- A systematic review in January 2024 analyzed 55 studies focusing on anxiety, depression, and the potential absence of alexithymia in acromegaly patients, using various medical databases.
- Findings show that anxiety and depression are prevalent in acromegaly patients, negatively affecting their health-related quality of life (HR-QoL), and highlight the need for early psychological assessment and integrated interventions to improve patient well-being.
Article Synopsis
- - Several studies indicate that chemical pollutants can disrupt endocrine functions and play a role in tumor development, particularly increasing instances of acromegaly in polluted regions.
- - The aryl hydrocarbon receptor (AHR) is linked to both cancer formation and detoxification, and its deregulation may influence pituitary tumors, especially those that secrete growth hormone (GH).
- - Despite some findings on the relationship between environmental pollutants and GH-secreting pituitary tumors, more research is necessary to clarify how AHR signaling and non-coding RNAs (ncRNAs) interact in this context.
Article Synopsis
- ACTH-independent Cushing syndrome (CS) is a rare condition in children, often linked to primary pigmented nodular adrenocortical disease (PPNAD), which is commonly associated with Carney complex (CNC), a genetic syndrome caused by mutations in the PRKAR1A gene.
- A 10-year-old boy presented with severe obesity and poor growth response despite dietary measures, which escalated over 10 months, leading to additional symptoms including hypertension and skin changes.
- After thorough testing, including imaging and genetic analysis, it was determined that he had ACTH-independent hypercortisolism due to bilateral micronodular adrenal hyperplasia, confirmed by a pathogenic variant in the PRKAR1A
Health-related quality of life (HRQoL) represents one of the most concerning aspects for cancer patients. The Healthy Eating Index (HEI) is an a priori diet quality index directly associated with health outcomes and HRQoL in cancer survivors in North American populations. We evaluated, in a Mediterranean population, the baseline associations between HEI-2015 and HRQoL in 492 women with breast cancer recruited in a DEDiCa lifestyle trial.
View Article and Find Full Text PDF