Publications by authors named "F Farinas"
Zoonotic parasitic diseases are considered a global threat to public health. In this sense, canines and felines may be infected by different cosmopolitan parasites, with playgrounds serving as an important focus of infection for humans, as well as domestic or wild animals. Knowledge of the epidemiological situation of parasites in animal reservoirs integrated into the environment, identifying the spread pathways, is a key element for an effective response to this threat.
View Article and Find Full Text PDFThe feline calicivirus (FCV) causes infections in cats all over the world and seems to be related to a broad variety of clinical presentations, such as feline chronic gingivostomatitis (FCGS), a severe oral pathology in cats. Although its etiopathogeny is largely unknown, FCV infection is likely to be a main predisposing factor for developing this pathology. During recent years, new strategies for treating FCGS have been proposed, based on the use of mesenchymal stem cells (MSC) and their regenerative and immunomodulatory properties.
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- Weaning in piglets can trigger inflammation in the intestine, which may hinder their health and increase disease risk, but nutritional strategies like fungal fermented products could help improve their gut health and immune response.
- In this study, a blend of mannan-rich hydrolyzed copra meal and fermented rye with Agaricus subrufescens was found to significantly reduce certain pro-inflammatory cytokines in the intestines of post-weaning piglets, particularly noticeable by day 15.
- The results indicated that the feed additive not only modulated immune responses but also affected the structure of the intestines, showing changes in villus height over time and a decrease in the amount of Immunoglobulin A-producing cells, suggesting improved intestinal health.
Feline chronic gingivostomatitis (FCGS) is a pathology with a complicated therapeutic approach and with a prevalence between 0.7 and 12%. Although the etiology of the disease is diverse, feline calicivirus infection is known to be a predisposing factor.
View Article and Find Full Text PDFThe study of cancer biology should be based around a comprehensive vision of the entire tumor ecosystem, considering the functional, bioenergetic and metabolic state of tumor cells and those of their microenvironment, and placing particular importance on immune system cells. Enhanced understanding of the molecular bases that give rise to alterations of pathways related to tumor development can open up new therapeutic intervention opportunities, such as metabolic regulation applied to immunotherapy. This review outlines the role of various oncometabolites and immunometabolites, such as TCA intermediates, in shaping pro/anti-inflammatory activity of immune cells such as MDSCs, T lymphocytes, TAMs and DCs in cancer.
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