Oncogenic Functions of Alternatively Spliced Isoform in Retroperitoneal Liposarcoma.

Retroperitoneal liposarcoma (RPLPS) is one of the most common histologic subtypes of soft tissue sarcoma (STS). Complete surgical resection remains the mainstay treatment, while the high rate of locoregional recurrence constitutes the predominant cause of mortality. Well-differentiated (WDLPS) and dedifferentiated (DDLPS) liposarcoma are the most frequent subtypes of RPLPS and present amplified MDM2 gene as a hallmark.

Three-dimensional models: from cell culture to Patient-Derived Organoid and its application to future liposarcoma research.

Liposarcoma is one of the most common soft tissue sarcomas, however, its occurrence rate is still rare compared to other cancers. Due to its rarity, experiments are an essential approach to elucidate liposarcoma pathobiology. Conventional cell culture-based research (2D cell culture) is still playing a pivotal role, while several shortcomings have been recently under discussion.

Comprehensive analysis and human health risk assessment of tap water quality in Dhaka City, Bangladesh: Integrating source identification, index-based evaluation, and heavy metal assessment.

Despite potential contamination, tap water remains the primary source of drinking in megacities. However, the sources of heavy metal(oid)s contamination and associated health hazards have not been thoroughly addressed in many developing cities, including Dhaka. Therefore, we made the first attempt to assess tap water quality in Dhaka City using indices, identify pollution sources with state-of-the-art techniques, and quantify associated health risks.

Trophic status analysis and nutrient source allocation in urban lakes of Dhaka, Bangladesh: a comprehensive approach to eutrophication monitoring.

Urban lakes are vital to ecosystems, providing essential services and recreational spaces in densely populated megacities. However, rapid urbanization and anthropogenic activities, particularly eutrophication driven by macronutrient accumulation, severely threaten these water bodies. This study underscores the critical need for continuous trophic state monitoring to sustain fish, wildlife, and plant ecosystems.

Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids.

Hepatoblastoma, the most prevalent pediatric liver cancer, almost always carries a WNT-activating CTNNB1 mutation, yet exhibits notable molecular heterogeneity. To characterize this heterogeneity and identify novel targeted therapies, we perform comprehensive analysis of hepatoblastomas and tumor-derived organoids using single-cell RNA-seq/ATAC-seq, spatial transcriptomics, and high-throughput drug profiling. We identify two distinct tumor epithelial signatures: hepatic 'fetal' and WNT-high 'embryonal', displaying divergent WNT signaling patterns.