Publications by authors named "F Fanfarillo"
Alcohol consumption has been consistently linked to an increased risk of several cancers, including breast and ovarian cancer. Despite substantial evidence supporting this association, the precise mechanisms underlying alcohol's contribution to cancer pathogenesis remain incompletely understood. This narrative review focuses on the key current literature on the biological pathways through which alcohol may influence the development of breast and ovarian cancer.
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- - Fetal Alcohol Spectrum Disorders (FASD) refers to a variety of conditions caused by drinking alcohol during pregnancy, impacting the central nervous system, growth, and facial features.
- - Early screening for FASD is critical since there are no treatments; methods include assessing alcohol biomarkers in maternal blood and meconium, as well as using sensitive questionnaires to identify at-risk pregnancies.
- - The review emphasizes the importance of combining alcohol biomarkers with traditional screening tools to ensure more accurate detection and monitoring of alcohol consumption during pregnancy.
Article Synopsis
- Fetal Alcohol Spectrum Disorders (FASD) arise from prenatal alcohol exposure, leading to various physical and cognitive challenges, with a notable prevalence of 7.7 cases per 1,000 in the Western world.
- FASD includes conditions like alcohol-related neurodevelopmental disorders and fetal alcohol syndrome, with individuals affected often facing significant health issues and reduced lifespans, estimated at around 34 years for those with FAS.
- Prevention and early intervention are key in improving outcomes, yet public awareness about the risks of alcohol during pregnancy remains low, highlighting the need for increased education on this critical issue.
Nerve Growth Factor and the Role of Inflammation in Tumor Development.
Curr Issues Mol Biol
January 2024
Nerve growth factor (NGF) plays a dual role both in inflammatory states and cancer, acting both as a pro-inflammatory and oncogenic factor and as an anti-inflammatory and pro-apoptotic mediator in a context-dependent way based on the signaling networks and its interaction with diverse cellular components within the microenvironment. This report aims to provide a summary and subsequent review of the literature on the role of NGF in regulating the inflammatory microenvironment and tumor cell growth, survival, and death. The role of NGF in inflammation and tumorigenesis as a component of the inflammatory system, its interaction with the various components of the respective microenvironments, its ability to cause epigenetic changes, and its role in the treatment of cancer have been highlighted in this paper.
View Article and Find Full Text PDFNGF plays a crucial immunomodulatory role and increased levels are found in numerous tissues during autoimmune states. NGF directly modulates innate and adaptive immune responses of B and T cells and causes the release of neuropeptides and neurotransmitters controlling the immune system activation in inflamed tissues. Evidence suggests that NGF is involved in the pathogenesis of numerous immune diseases including autoimmune thyroiditis, chronic arthritis, multiple sclerosis, systemic lupus erythematosus, mastocytosis, and chronic granulomatous disease.
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