Structure-based targeting of the lipid A-modifying enzyme PmrC to contrast colistin resistance in .

Introduction: Antimicrobial-resistant pathogens are an ongoing threat to human and animal health. According to the World Health Organization (WHO), colistin is considered the last resort antibiotic against human infections due to multidrug-resistant Gram-negative organisms-including , a priority-1 pathogen. Despite colistin being considered a last resort antibiotic, transferable bacterial resistance to this drug has been reported in humans and animals.

Detecting images generated by diffusers.

In recent years, the field of artificial intelligence has witnessed a remarkable surge in the generation of synthetic images, driven by advancements in deep learning techniques. These synthetic images, often created through complex algorithms, closely mimic real photographs, blurring the lines between reality and artificiality. This proliferation of synthetic visuals presents a pressing challenge: how to accurately and reliably distinguish between genuine and generated images.

Correction to "Novel Antiproliferative Chimeric Compounds with Marked Histone Deacetylase Inhibitory Activity".

[This corrects the article DOI: 10.1021/ml5000959.].

Probing allosteric communication with combined molecular dynamics simulations and network analysis.

Understanding the allosteric mechanisms within biomolecules involved in diseases is of paramount importance for drug discovery. Indeed, characterizing communication pathways and critical hotspots in signal transduction can guide a rational approach to leverage allosteric modulation for therapeutic purposes. While the atomistic signatures of allosteric processes are difficult to determine experimentally, computational methods can be a remarkable resource.

Artificial light at night: a global disruptor of the night-time environment.

Light pollution is the alteration of the natural levels of darkness by an increased concentration of light particles in the night-time environment, resulting from human activity. Light pollution is profoundly changing the night-time environmental conditions across wide areas of the planet, and is a relevant stressor whose effects on life are being unveiled by a compelling body of research. In this paper, we briefly review the basic aspects of artificial light at night as a pollutant, describing its character, magnitude and extent, its worldwide distribution, its temporal and spectral change trends, as well as its dependence on current light production technologies and prevailing social uses of light.