Bioinformatics design of peptide binding to the human cardiac troponin I (cTnI) in biosensor development for myocardial infarction diagnosis.

Cardiovascular disease has reached a mortality rate of 470,000 patients each year. Myocardial infarction accounts for 49.2% of these deaths, and the cTnI protein is a crucial target in diagnosing myocardial infarction.

The molecular interaction of six single-stranded DNA aptamers to cardiac troponin I revealed by docking and molecular dynamics simulation.

Cardiac troponin I (cTnI) is a cardiac biomarker for diagnosing ischemic heart disease and acute myocardial infarction. Current biochemical assays use antibodies (Abs) due to their high specificity and sensitivity. However, there are some limitations, such as the high-cost production of Abs due to complex instruments, reagents, and steps; the variability of Abs quality from batch to batch; the low stability at high temperatures; and the difficulty of chemical modification.

Transmission and Profile of COVID-19 in Children in North Sumatera, Indonesia.

Background: In December 2019, a cluster of viral pneumonia cases, later identified as coronavirus disease 2019 (COVID-19), was first reported in Wuhan, China, and then continued to spread to other parts of the world. COVID-19 is thought to be more prevalent in adults than children; therefore, information about COVID-19 burden and characteristics in children is lacking.

Methods: We gathered data on the profile and transmission in children with COVID-19 from data collected by the North Sumatera Provincial Health Office team.

Survival, Development, and Fecundity of (J.E. Smith) (Lepidoptera: Noctuidae) on Various Host Plant Species and Their Implication for Pest Management.

is Indonesia's relatively new invasive polyphagous insect pest. So far, infestation has only been reported in corn and rice in Indonesia. However, is known to feed on many commercial crops in other countries.