Publications by authors named "F F U Santos-Junior"
Article Synopsis
- Five new lignanamides and ten known amides were extracted from the roots' chloroform extract, with new compounds identified through NMR and mass spectrometry.
- The absolute configuration of one compound was determined using ECD experiments and quantum mechanical calculations.
- The anti-inflammatory effects of these compounds were tested on macrophages, showing that all reduced nitric oxide levels, while one compound did not significantly affect IL-10 levels, indicating potential anti-inflammatory properties.
Seven new abietane diterpenoids, comprising medusanthol A-G (-, , -) and two previously identified analogs ( and ), were isolated from the hexane extract of the aerial parts of The structures of the compounds were elucidated by HRESIMS, 1D/2D NMR spectroscopic data, IR spectroscopy, NMR calculations with DP4+ probability analysis, and ECD calculations. The anti-neuroinflammatory potential of compounds - was evaluated by determining their ability to inhibit the production of nitric oxide (NO) and the proinflammatory cytokine TNF-α in BV2 microglia stimulated with LPS and IFN-γ. Compounds - and exhibited decreased NO levels at a concentration of 12.
View Article and Find Full Text PDFHeliannuols are a unique class of sesquiterpenes isolated mostly from , commonly known as sunflower. The interesting allelopathic properties, combined with their unprecedented carbon skeletons, have drawn wide attention to phytochemistry and synthetic groups. So far, 14 heliannuols (heliannuols A-N) have been described in the literature, although some of them have not yet been validated by total synthesis.
View Article and Find Full Text PDFMilligram scale enantioresolution of promethazine and its main metabolites, determination of their absolute configuration and assessment of enantioselective effects on human SY-SY5Y cells.
J Pharm Biomed Anal
August 2024
Article Synopsis
- The recent rise in pharmaceutical misuse, especially among teens, highlights serious health risks associated with drugs like promethazine (PMZ), often consumed in a dangerous concoction known as "Purple Drank."
- Newly conducted research focused on separating PMZ and its toxic metabolites into their individual chiral forms, revealing significant differences in toxicity among them.
- The study found that one metabolite, (R,S)-DMPMZ, was much more toxic than PMZ itself, pointing to a potential risk in its metabolic activation, while another metabolite, (R,S)-PMZSO, showed little to no toxicity, indicating a detoxification process.
Objective: To determine the Intraclass Correlation Coefficient (ICC), Standard Error of Measurement (SEM), Minimum Detectable Change (MDC), and the Minimum Clinically Important Difference (MCID) of the isometric measurements of muscle strength of trunk extension and of flexion and knee extension at maximum contraction in healthy, paraplegic, and amputee individuals, by using an isometric dynamometer with a belt for stabilization.
Methods: An observational cross-sectional study was carried out to assess the reliability of a portable isometric dynamometer in the trunk extension and flexion and knee extension movements of each group.
Results: In all measurements, ICC ranged from 0.