Publications by authors named "F F Trigo"
Fañanas cells (FCs) are cerebellar glia of unknown function. First described more than a century ago, they have been almost absent from the scientific literature ever since. Here, we combined whole-cell, patch clamp recordings, near-UV laser photolysis, dye-loading and confocal imaging for a first characterization of FCs in terms of their morphology, electrophysiology and glutamate-evoked currents.
View Article and Find Full Text PDFBackground: Patients with secondary acute myeloid leukemia who previously received hypomethylating agents for prior myeloid neoplasms (HMA-sAML) face a dismal prognosis.
Methods: The authors analyze the characteristics, therapeutic approaches, and outcomes of patients with HMA-sAML from the Programa Español para el Tratamiento de Hemopatías Malignas (PETHEMA) registry.
Results: A total of 479 patients were included, mostly from prior myelodysplastic syndrome (84%).
Objectives: To characterize variations in real-world treatment patterns in multiple myeloma (MM) in Portugal over a 5-year period.
Methods: A retrospective cohort multicenter study using secondary data of national hospital drug consumption database from 11 Portuguese public hospitals between 2017 and 2022.
Results: Number of MM-treated patients increased 53% over 5 years (from 825 to 1266 patients).
Presynaptic ionotropic receptors in the cerebellar cortex: Just the tip of the iceberg?
Neuroscience
November 2024
The presence of ionotropic receptors to neurotransmitters in presynaptic structures is well documented in many synapses of the mammalian brain. However, due to technical limitations, the actual prevalence of presynaptic ionotropic receptors, as well as their potential functional roles, have remained largely uncertain. The relatively simple and regular organization of neurites in the cerebellar cortex has offered a unique opportunity to bridge this gap of knowledge, by systematically probing the presence and role of presynaptic ionotropic receptors at various synapses.
View Article and Find Full Text PDFArticle Synopsis
- - Febrile neutropenia (FN) is a serious condition, especially for patients in hematology and oncology, where there's a risk of multidrug-resistant bacteria, leading to varied antimicrobial practices due to differing guidelines.
- - A survey of Portuguese hematologists explored treatment approaches in FN management, using clinical scenarios to gather data on preferences for narrow-spectrum antibiotics, short-course therapy, and de-escalation strategies.
- - Results showed all participants preferred narrow-spectrum antibiotics, while a minority chose short-course therapy or de-escalation, indicating a need for better protocols and interventions to optimize antibiotic use in FN cases.