Publications by authors named "F F Mosha"
Background: High-grade resistance to sulfadoxine-pyrimethamine in East and Southern Africa has prompted numerous trials evaluating intermittent preventive treatment in pregnancy (IPTp) with dihydroartemisinin-piperaquine as an alternative to sulfadoxine-pyrimethamine.
Methods: We conducted individual participant data meta-analyses of randomised trials comparing IPTp with dihydroartemisinin-piperaquine to sulfadoxine-pyrimethamine on maternal, birth, and infant outcomes. We searched the WHO International Clinical Trials Registry Platform, ClinicalTrials.
Background: Insecticide treated nets (ITNs) are the most important malaria prevention tool in Africa but the rise of pyrethroid resistance in mosquitoes is likely impeding control. WHO has recommended a novel pyrethroid-pyrrole ITN following evidence of epidemiological benefit in two cluster-randomised, controlled trials (CRTs). It remains unclear how effective more costly pyrethroid-pyrrole ITNs are compared with other tools, or whether they should be deployed when budgets are limited.
View Article and Find Full Text PDFEvaluation of bio-efficacy of field-aged novel long-lasting insecticidal nets (PBO, chlorfenapyr or pyriproxyfen combined with pyrethroid) against () in Tanzania.
Curr Res Parasitol Vector Borne Dis
September 2024
Article Synopsis
- Next-generation insecticide-treated bed nets (ITNs), which combine new insecticides or add synergists, are essential for fighting malaria, especially in regions with mosquito resistance to traditional pyrethroid nets.
- A study in Misungwi, Tanzania, tested the effectiveness of three types of these new nets over three years, comparing them against the standard Interceptor net; tests revealed they showed better efficacy against malaria-carrying mosquitoes.
- While over 80% of the new nets were effective after three years for susceptible mosquitoes, their effectiveness against resistant strains declined over time, indicating the need for ongoing research and potential replacements for long-term malaria control.
New classes of long-lasting insecticidal nets (LLINs), have been recommended by the World Health Organization (WHO) to control malaria vectors resistant to pyrethroid insecticides. This study was nested in a large-scale cluster-randomized controlled trial conducted (cRCT) in Tanzania. A series of experimental hut trials (EHTs) aimed to evaluate the bio-efficacy of trial LLINs on mosquito indicators most pertinent to malaria transmission over 3 years of use in the community in order to better understand the outcomes of the cRCT.
View Article and Find Full Text PDFAntimicrobial resistance (AMR) is a significant global public health threat. This review presents the most recent in-depth review of the situation of the main AMR types in relation to the most commonly prescribed antibiotics in the World Health Organization (WHO) African Region. Underlying genes of resistance have been analyzed where possible.
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