Signaling pathways and therapeutic approaches in glioblastoma multiforme (Review).

Glioblastoma multiforme (GBM) is the most aggressive type of primary brain tumor and is associated with a poor clinical prognosis. Despite the progress in the understanding of the molecular and genetic changes that promote tumorigenesis, effective treatment options are limited. The present review intended to identify and summarize major signaling pathways and genetic abnormalities involved in the pathogenesis of GBM, as well as therapies that target these pathways.

[Surgical policy in treatment of patients with infected aortofemoral bifurcation allografts].

Described in the article are the results of treating a total of 44 patients who endured repeat operations for infection of aortofemoral bifurcation allografts over the period between 2001 and 2018. These patients had previously undergone reconstructive operations using various synthetic grafts for lower limb ischaemia on the background of lower-limb artery atherosclerosis and infrarenal aortic aneurysms. Infection of synthetic vascular allografts in these patients was observed both in the immediate and remote postoperative periods.

[Surgical treatment of a patient presenting with an infected aortofemoral bifurcation prosthesis].

Described herein is a clinical case report regarding successive treatment of a patient presenting with total infection of an aortofemoral bifurcation vascular prosthesis and a purulent fistula in the left iliac-inguinal region. The patient was subjected to removal of the infected aortofemoral bifurcation prosthesis, followed by autovenous aortofemoral bifurcation prosthetic repair. There were no pyo-haemorrhagic complications in the postoperative period.

[Role of reconstructive vascular surgery in patients with diabetic angiopathy].

Treatment results were analyzed in 1244 patients with diabetic angiopathy. 882 of them had necrotic suppurative affection of feet. Distal affection predominated among patients with neuroischemic form of diabetic foot syndrome.