Aluminum chloride (AlCl), a known neurotoxic and Alzheimerogenic metal disrupts redox homeostasis which plays a pivotal role in pathophysiology of neurodegenerative disorders, particularly cognitive decline. The current study was designed to unveil the long-term neuroprotective outcomes and efficacy of CoQ10 and curcumin low dose (100 mg/kg each) combination in 18-months old geriatric male Balb/c mice subjected to AlCl-prompted memory derangements (200 mg/kg in water bottles) for 28 days. The neuroprotective properties driven by antioxidant mechanisms were assessed via observing cellular pathology in key-memory related brain regions including the cornuammonis (CA3 and DG) and cortex 2/3 layer.
View Article and Find Full Text PDFBackground Hypoglycemia, where blood glucose is ≤70 mg/dL, is a serious diabetic complication with high individual and community costs. This study aimed to investigate the level of awareness of hypoglycemic episodes among type 2 diabetic patients in the Aseer region, Saudi Arabia. Methods This cross-sectional study was conducted in the Aseer region of Saudi Arabia over 9 months, among 235 type 2 diabetic patients.
View Article and Find Full Text PDFThis study aims to conduct a thorough analysis of the existing studies to determine how patients with acute cholecystitis (AC) respond to surgical intervention at different times following their diagnosis. To locate studies that met the inclusion criteria, a thorough computerized search of relevant databases was carried out. A comprehensive search was carried out on PubMed, SCOPUS, Science Direct, Cochrane Library, and Web of Science to locate relevant material.
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