R21 in Matrix-M adjuvant in UK malaria-naive adult men and non-pregnant women aged 18-45 years: an open-label, partially blinded, phase 1-2a controlled human malaria infection study.

Background: R21 is a novel malaria vaccine, composed of a fusion protein of the malaria circumsporozoite protein and hepatitis B surface antigen. Following favourable safety and immunogenicity in a phase 1 study, we aimed to assess the efficacy of R21 administered with Matrix-M (R21/MM) against clinical malaria in adults from the UK who were malaria naive in a controlled human malaria infection study.

Methods: In this open-label, partially blinded, phase 1-2A controlled human malaria infection study undertaken in Oxford, Southampton, and London, UK, we tested five novel vaccination regimens of R21/MM.

Acceptability of and attitudes to the therapeutic use of cannabis and cannabidiol in people with Parkinson's disease: A French survey.

Introduction: Cannabis and cannabidiol (CBD) may potentially alleviate symptoms and improve the quality of life of people with Parkinson's disease (PD), although clinical results to date have provided conflicting evidence. In France, cannabis use is illegal outside the current restricted medical cannabis experimental framework which does not include PD as an eligible condition. In contrast, CBD products are legal and are easily available.

Combined diaphragmatic hernia repair and sleeve gastrectomy in an obese patient: A case report.

Introduction: Asymptomatic diaphragmatic hernia is generally rare among adults. Nonetheless, a subset of these patients can live a normal life and be exposed to many diseases, including obesity. When this rare event happens, surgical management can offer a solution to both problems simultaneously.

Purification of LiCO Obtained through Pyrometallurgical Treatment of NMC Black Mass from Electric Vehicle Batteries.

The recycling of lithium batteries is essential for a sustainable energy transition. However, impurities in the products obtained from the black mass can lower their market value. In this work, lithium carbonate, which has the highest market share among lithium-based products, is purified using distilled water at controlled temperature, time and stirring speed.

Clust&See3.0 : clustering, module exploration and annotation.

Background: Cytoscape is an open-source software to visualize and analyze networks. However, large networks, such as protein interaction networks, are still difficult to analyze as a whole.

Methods: Here, we propose Clust&See3.