Publications by authors named "F Engelmann"

Yellow fever virus (YFV) is endemic in >40 countries and causes viscerotropic disease with up to 20%-60% mortality. Successful live-attenuated yellow fever (YF) vaccines were developed in the mid-1930s, but their use is restricted or formally contraindicated in vulnerable populations including infants, the elderly, and people with compromised immune systems. In these studies, we describe the development of a next-generation hydrogen peroxide-inactivated YF vaccine and determine immune correlates of protection based on log neutralizing index (LNI) and neutralizing titer-50% (NT) studies.

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Article Synopsis
  • Understanding the tumor immune microenvironment (TIME) is crucial for developing better cancer therapies, and multiplexed tissue imaging is a key tool for studying this complexity.
  • A comprehensive immunophenotyping panel with over 121 markers was created using advanced imaging techniques to analyze primary cancer tissues, focusing on tumor heterogeneity and immune cell interactions.
  • The study revealed important findings about the interactions between immunosuppressive myeloid cells and exhausted T cells in hepatocellular carcinoma, demonstrating the value of spatial profiling in uncovering clinically relevant tumor features.
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The ForMAX beamline at the MAX IV Laboratory provides multiscale and multimodal structural characterization of hierarchical materials in the nanometre to millimetre range by combining small- and wide-angle X-ray scattering with full-field microtomography. The modular design of the beamline is optimized for easy switching between different experimental modalities. The beamline has a special focus on the development of novel fibrous materials from forest resources, but it is also well suited for studies within, for example, food science and biomedical research.

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The objective of this study is to assess the suitability of vitrification cryo-plate (V cryo-plate) and dehydration cryo-plate (D cryo-plate) methods for the long-term conservation of eight autochthonous L. genotypes originating from the Balkan Peninsula region. In vitro shoot tips were briefly pre-cultured for 1 day at 23 °C in the dark on a medium containing 0.

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