Platinum-based combination chemotherapy in non-small cell lung carcinoma.

A series of 35 patients with advanced non-small cell lung cancer were treated with combination chemotherapy consisting of cis-diamminedichloro platinum (II), Adriamycin, 5-fluorouracil, methotrexate and vincristine. The objective response rate was 37.1% and the overall median survival 52.

Hierarchical organization, integrations in biology and cancer, balance loss, and a question on modernism.

The hierarchical organization of biological processes is considered in the light of universal interrelationships of each and every factor affecting open systems such as human life. The maintenance of health and/or the production of disease are viewed at different levels of biological organization as related to the dualistic concept. The relative effects of environmental versus genetic tendencies in the pathogenesis of "disease" are mathematically formulated as related to time and location.

Surgical management of metastases to the lung.

Our experience with 234 patients having resection of metastatic lesions of lung is reviewed. Most bilateral lung metastases were removed though a median sternotomy. Exploration of the contralateral lung with simultaneous removal of all lesions is possible through such an incision, and moreover, it appears to give less pain postoperatively.

Surgical treatment of locally far-advanced lung carcinoma.

It has been our policy to employ radical lung resection as a primary treatment whenever possible in locally far-advanced lung cancer. In order to assess the therapeutic results, a total of 132 patients with locally far-advanced lung cancer who had radical lung resection were reviewed. Postoperative mortality was 10%.