Publications by authors named "F E Preston"

In collaboration with Australian lamb supply chains, an integer linear programming model was developed for use by processors to optimally allocate carcasses to different cutting plans for implementation in a boning room on a daily or lot basis. This tactical carcass optimisation tool (TCOT) addresses the daily challenge of developing operational plans to process carcasses into products whilst maximising profitability subject to constraints on carcass availability, variability of carcass weight and fatness, number of product orders, product size and retail prices. Predicted weights for all available products were derived from cut-weight prediction algorithms established from the combination of carcass weight and fatness ranges.

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Article Synopsis
  • The study evaluated the link between SGLT2 inhibitors and GLP-1 receptor agonists in relation to gout occurrence among type 2 diabetes patients using real-world data.
  • A cohort study was conducted, where patients on metformin or insulin with either SGLT2i or GLP-1Ra were matched based on characteristics and assessed over five years for gout incidence.
  • Results indicated that SGLT2i use significantly reduced gout incidence compared to control groups, whereas GLP-1Ra showed no significant difference, suggesting that SGLT2i might be a better option for preventing gout in these patients.
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Purpose: To determine the degree of static eyelid asymmetry required to be perceptible and whether this is affected by image inversion.

Methods: Images of 3 volunteers were digitally manipulated to have eyelid asymmetry of 0.5 mm, 1 mm, or 1.

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Introduction: A safety data sheet (SDS) is an established hazard communication tool for chemicals, for which no comparable document exists in the biotherapeutics industry. As the cell and gene therapy (CGT) field expands, industry leaders have identified a growing need to address this gap in communication of the unique occupational health and safety risks posed by CGT materials and products.

Methods: Following the sections of a traditional chemical SDS, information was modified by industry subject matter experts, relevant to CGT biological materials.

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Introduction: This article provides a strategy by which a manufacturing process with a Biosafety Level 2 (BL2) designation can be downgraded to Biosafety Level 1 (BL1). The principles of the downgrading process are based on the robust contamination controls in clinical and commercial manufacturing, which typically are not part of Research and Development processes. These strict requirements along with the application of current Good Manufacturing Practice (cGMP) principles provide a framework by which processes can be suitably managed and controlled to mitigate biohazard risk, specifically for cell lines that may be contaminated with human pathogenic viral agents.

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