Human-derived microRNA 21 regulates indole and L-tryptophan biosynthesis transcripts in the gut commensal .

Unlabelled: In the gut, microRNAs (miRNAs) produced by intestinal epithelial cells are secreted into the lumen and can shape the composition and function of the gut microbiome. Crosstalk between gut microbes and the host plays a key role in irritable bowel syndrome (IBS) and inflammatory bowel diseases, yet little is known about how the miRNA-gut microbiome axis contributes to the pathogenesis of these conditions. Here, we investigate the ability of miR-21, a miRNA that we found decreased in fecal samples from IBS patients, to associate with and regulate gut microbiome function.

Advancements in drug discovery: integrating CADD tools and drug repurposing for PD-1/PD-L1 axis inhibition.

Despite significant strides in improving cancer survival rates, the global cancer burden remains substantial, with an anticipated rise in new cases. Immune checkpoints, key regulators of immune responses, play a crucial role in cancer evasion mechanisms. The discovery of immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 has revolutionized cancer treatment, with monoclonal antibodies (mAbs) becoming widely prescribed.

Deep orbital puncture of the superior ophthalmic vein for embolization of indirect carotid-cavernous fistula: a case report, technical note and review of the current literature.

Purpose: Carotid-cavernous fistulas (CCFs) are abnormal connections between the carotid artery and cavernous sinus, often causing ocular symptoms like chemosis, proptosis, and diplopia. Endovascular embolization is the preferred treatment, typically performed via the transfemoral transvenous route through the inferior petrosal sinus (IPS). However, we present a case and a systematic review of indirect CCF treated through deep orbital puncture of the superior ophthalmic vein (SOV) for embolization.

Mineral and trace element analysis of non-conventional food plants using ICP OES and chemometric techniques.

Non-conventional food plants (or non-conventional edible plants) have the potential to serve as an excellent nutritional alternative while promoting the circular economy. Given the nutritional potential of non-conventional food plants, this study aimed to investigate and determine the composition of these plants using inductively coupled plasma optical emission spectroscopy (ICP OES) combined with chemometric techniques. In this context, the following non-conventional food plant species were evaluated: serralha (Sonchus oleraceus), two species of ora-pro-nóbis, Pereskia grandifolia and Pereskia aculeata, peixinho (Nematanthus gregarius), alfavaca (Ocimum basilicum), taioba (Xanthosoma sagittifolium), capeba (Pothomorphe umbellata), tranchagem (Plantago major), and bardana (Arctium lappa).