Corticosteroids reduce pathological angiogenesis yet compromise reparative vascular remodeling in a model of retinopathy.

Tissue inflammation is often broadly associated with cellular damage, yet sterile inflammation also plays critical roles in beneficial tissue remodeling. In the central nervous system, this is observed through a predominantly innate immune response in retinal vascular diseases such as age-related macular degeneration, diabetic retinopathy, and retinopathy of prematurity. Here, we set out to elucidate the dynamics of the immune response during progression and regression of pathological neovascularization in retinopathy.

Unravelling the mechanics of gastric tissue: A comparison of constitutive models, damage probability and microstructural insights.

With the increasing prevalence of obesity worldwide, bariatric surgery is becoming increasingly common. However, the mechanic of the gastric wall related to bariatric surgery complications remains to be investigated. This study aims to understand mechanical behaviour of stomach by developing advanced material laws for gastric tissue incorporating microstructure.

Surgical management of rectal cancer with synchronous treatment of prostate cancer.

Purpose: To assess the safety and efficacy of synchronous treatments for rectal (RC) and prostate (PC) cancers.

Methods: Single-center retrospective study (2007-2021) of patients treated with neoadjuvant radiotherapy (RT) and total mesorectal excision (TME) for RC with synchronous PC treatment. The endpoints were 30-day postoperative severe complications, R0 resection rates, 3-year disease-free survival (DFS) and 3-year overall survival (OS).

Combining metabolic flux analysis with proteomics to shed light on the metabolic flexibility: the case of Hildenborough.

Introduction: Hildenborough is a gram-negative anaerobic bacterium belonging to the sulfate-reducing bacteria that exhibits highly versatile metabolism. By switching from one energy mode to another depending on nutrients availability in the environments" it plays a central role in shaping ecosystems. Despite intensive efforts to study energy metabolism at the genomic, biochemical and ecological level, bioenergetics in this microorganism remain far from being fully understood.

Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results.

Compromised vascular endothelial barrier function is a salient feature of diabetic complications such as sight-threatening diabetic macular edema (DME). Current standards of care for DME manage aspects of the disease, but require frequent intravitreal administration and are poorly effective in large subsets of patients. Here we provide evidence that an elevated burden of senescent cells in the retina triggers cardinal features of DME pathology and conduct an initial test of senolytic therapy in patients with DME.