Publications by authors named "F E Holmes"
The Arctic rapidly transforms due to global warming and increased human activities, triggering complex changes at unprecedented speeds that challenge conventional institutional responses. We analyse these changes through the lenses of social, political, and environmental boundaries and investigate their impacts on both inhabitants' livelihoods and the region's political framework. Employing an interdisciplinary approach, we highlight the complexities of understanding the interplay among global, regional, and local dynamics in an era where human and non-human aspects are entwined.
View Article and Find Full Text PDFImportance: Noninvasive tests for colorectal cancer screening must include sensitive detection of colorectal cancer and precancerous lesions. These tests must be validated for the intended-use population, which includes average-risk individuals 45 years or older.
Objective: To evaluate the sensitivity and specificity of a noninvasive, multitarget stool RNA (mt-sRNA) test (ColoSense) test compared with results from a colonoscopy.
Article Synopsis
- - ExteNET, a phase 3 clinical trial, studied the effects of neratinib, a drug used after trastuzumab therapy, on improving invasive disease-free survival in women with early-stage HER2-positive breast cancer.
- - The trial randomly assigned 2,840 eligible women to receive either neratinib or a placebo for one year and analyzed overall survival after a median follow-up of 8.1 years.
- - Results showed that the overall survival rates were similar between the neratinib group (90.1%) and placebo group (90.2%), indicating that neratinib did not significantly improve survival over placebo.
The nucleus of the solitary tract (NTS) contains pro-opiomelanocortin (POMC) neurons that are 1 of the 2 major sources of β-endorphin in the brain. The functional role of these NTS POMC neurons in nociceptive and cardiorespiratory function is debated. We have shown that NTS POMC optogenetic activation produces bradycardia and transient apnoea in a working heart-brainstem preparation and chemogenetic activation with an engineered ion channel (PSAM) produced opioidergic analgesia in vivo.
View Article and Find Full Text PDFIntroduction: The Maternal and Child Health (MCH) Pipeline Training Program, promotes development of a diverse health workforce by training undergraduate students from underrepresented minorities. We aimed to evaluate the success of this program based on three domains: (1) demographic characteristics, (2) academic and career development, and (3) attitudes towards the field of MCH and the training programs among graduates.
Methods: Three domains of success were determined through a collaborative effort between current program directors and the funding agency project officers.