The role of stereochemistry in the anticancer activity of Re(I) tricarbonyl complexes.

Cancer is a leading cause of death worldwide, accounting for about one among six deaths, so the quest for new and improved therapies is of crucial importance. The discovery of cisplatin as an anticancer agent has paved the way for the development of other metal-based therapeutic agents and Re(I)-based candidates have been recently found to show promising results. It is known as well that chirality plays a central role in the interactions of metal-based drugs with intrinsically chiral biomolecules such as membrane transport proteins or DNA.

The Antioxidant Properties of Glucosinolates in Cardiac Cells Are Independent of HS Signaling.

The organic sulfur-containing compounds glucosinolates (GSLs) and the novel gasotransmitter HS are known to have cardioprotective effects. This study investigated the antioxidant effects and HS-releasing potential of three GSLs ((3)-4-(methylsulfanyl)but-3-enyl GSL or glucoraphasatin, 4-hydroxybenzyl GSL or glucosinalbin, and ()-6-(methylsulfinyl)hexyl GSL or glucohesperin) in rat cardiac cells. It was found that all three GSLs had no effect on cardiac cell viability but were able to protect against HO-induced oxidative stress and cell death.

Motion In-Betweening via Deep ∆-Interpolator.

We show that the task of synthesizing human motion conditioned on a set of key frames can be solved more accurately and effectively if a deep learning based interpolator operates in the delta mode using the spherical linear interpolator as a baseline. We empirically demonstrate the strength of our approach on publicly available datasets achieving state-of-the-art performance. We further generalize these results by showing that the ∆-regime is viable with respect to the reference of the last known frame (also known as the zero-velocity model).

A short history of the successes and failures of the international climate change negotiations.

The last 35 years have been a period of intense and continuous international negotiations to deal with climate change. During the same period of time humanity has doubled the amount of anthropogenic carbon dioxide in the atmosphere. There has, however, been progress and some notable successes in the negotiations.

Mass spectrometry dataset of LC-MS lipidomics analysis of optic nerve.

CNS injuries of the anuran amphibian, , are uniquely suited for studying the molecular compositions of neuronal regeneration of retinal ganglion cells (RGC) due to a functional recovery of optic axons disparate to adult mammalian analogues. RGCs and their optic nerve axons undergo irreversible neurodegeneration in glaucoma and associated optic neuropathies, resulting in blindness in mammals. Conversely, demonstrates RGC lifetime-spanning regenerative capabilities after optic nerve crush [1], inciting opportunities to compare de novo regeneration and develop efficient pharmaceutical approaches for vision restoration.