Breaking sedentary behavior among university students: the interest of incorporating cycling desks concurrently with an academic task at light intensity.

: University students experience ≈ 9 h of sitting/day, which may support interventions like active desks. University students ( = 24) Method: Randomized crossover trial aimed to compare effects of sitting (SED), low and moderate-intensity cycling desks (CD; CD) concurrent to an academic task (30-minute video + written exam). Selective visual attention (Tobii Glasses 2) was measured throughout the intervention, and workload (NASA-TLX) and anxiety (POMS-SF) were assessed before and after the video and post-exam.

Spatial transcriptomics reveals substantial heterogeneity in triple-negative breast cancer with potential clinical implications.

While triple-negative breast cancer (TNBC) is known to be heterogeneous at the genomic and transcriptomic levels, spatial information on tumor organization and cell composition is still lacking. Here, we investigate TNBC tumor architecture including its microenvironment using spatial transcriptomics on a series of 92 patients. We perform an in-depth characterization of tumor and stroma organization and composition using an integrative approach combining histomorphological and spatial transcriptomics.

AI-guided identification of risk variants for adrenocortical tumours in p.R337H carrier children: a genetic association study.

Background: Adrenocortical tumours (ACT) in children are part of the Li-Fraumeni cancer spectrum and are frequently associated with a germline pathogenic variant. p.R337H is highly prevalent in the south and southeast of Brazil and predisposes to ACT with low penetrance.

Evaluation of safety margins for cone beam CT-based adaptive prostate radiotherapy.

Adaptive radiotherapy is characterized by the use of a daily imaging system, such as CBCT (Cone-Beam Computed Tomography) images to re-optimize the treatment based on the daily anatomy and position of the patient. By systematically re-delineating the Clinical Target Volume (CTV) at each fraction, target delineation uncertainty features a random component instead of a pure systematic. The goal of this work is to identify the random and systematic contributions of the delineation error and compute a new relevant Planning Target Volume (PTV) safety margin.