Publications by authors named "F Ducancel"
Purpose: Airborne pathogen scan penetrate in human respiratory tract and can cause illness. The use of animal models to predict aerosol deposition and study respiratory disease pathophysiology is therefore important for research and a prerequisite to test and study the mechanism of action of treatment. NHPs are relevant animal species for inhalation studies because of their similarities with humans in terms of anatomical structure, respiratory parameters and immune system.
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- Preclinical studies using macaques are important for understanding respiratory effects, but they are challenging and costly due to the animals' sensitivity and accessibility issues.
- An in vitro anatomical model of macaque airways was created using 3D printing to mimic their breathing and evaluate aerosol deposition patterns while minimizing the use of animals.
- The in vitro model showed similar total aerosol deposition to live macaques, but with different distribution patterns, indicating it can be a valuable tool for predicting aerosol behavior in respiratory research.
Article Synopsis
- - Respiratory pathogens are a significant threat to global health and can lead to new pandemics, as shown by the COVID-19 outbreak.
- - Despite advancements in biotechnology resulting in new therapies and vaccines, effective solutions for many respiratory diseases are still lacking.
- - The review emphasizes the importance of non-human primate models in preclinical research to improve the development of prevention and treatment strategies for human respiratory infections.
Animal venoms are rich in hundreds of toxins with extraordinary biological activities. Their exploitation is difficult due to their complexity and the small quantities of venom available from most venomous species. We developed a Venomics approach combining transcriptomic and proteomic characterization of 191 species and identified 20,206 venom toxin sequences.
View Article and Find Full Text PDFDiversity in sequences, post-translational modifications and expected pharmacological activities of toxins from four Conus species revealed by the combination of cutting-edge proteomics, transcriptomics and bioinformatics.
Toxicon
May 2017
Venomous animals have developed a huge arsenal of reticulated peptides for defense and predation. Based on various scaffolds, they represent a colossal pharmacological diversity, making them top candidates for the development of innovative drugs. Instead of relying on the classical, low-throughput bioassay-guided approach to identify innovative bioactive peptides, this work exploits a recent paradigm to access to venom diversity.
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