Publications by authors named "F Droege"
Article Synopsis
- - Hereditary hemorrhagic telangiectasia (HHT) is a rare condition that leads to dilated blood vessels and has been linked to a higher prevalence of infections and allergies in affected individuals.
- - In a study, 430 patients with HHT completed a survey, revealing that they experienced significantly more allergies, particularly type I allergies, along with a higher incidence of infections like sinusitis and pulmonary infections, compared to their non-affected counterparts.
- - The findings highlight the need for increased awareness and recommendations for patients with pulmonary arteriovenous malformations (PAVMs) to take prophylactic antibiotics, as many do not do so despite their higher risk of complications.
Article Synopsis
- A postal survey was conducted among 161 German ENT departments to evaluate the diagnostic effectiveness and complication rates of fine-needle aspiration (FNA) and core needle biopsy (CNB) in the thyroid gland, salivary glands, and lymph nodes.
- The response rate was 45%, with many clinics not performing these procedures due to a lack of pathologist expertise.
- FNA was more commonly used than CNB, achieving 63% meaningful findings for FNA and 83% for CNB, with very few cases reporting potential tumor cell spread, indicating varying practices across Germany.
Patients with HPV-localized head and neck cancer (HNC) show inferior outcomes after surgery and radiochemotherapy compared to HPV-associated cancers. The underlying mechanisms remain elusive, but differences in immune status and immune activity may be implicated. In this study, we analyzed immune profiles of CD8 T cells and myeloid-derived suppressor cells (MDSC) in HPV versus HPV disease.
View Article and Find Full Text PDFThe interplay between hypoxia-inducible factors (HIFs) and transforming growth factor beta (TGF-β) is critical for both inflammation and angiogenesis. In hereditary hemorrhagic telangiectasia (HHT), we have previously observed that impairment of the TGF-β pathway is associated with downregulation of HIF-1α. HIF-1α accumulation is mandatory in situations of altered energy demand, such as during infection or hypoxia, by adjusting cell metabolism.
View Article and Find Full Text PDFThe transforming growth factor β (TGF-β)/ALK1/ENG signaling pathway maintains quiescent state of endothelial cells, but at the same time, it regulates neutrophil functions. Importantly, mutations of this pathway lead to a rare autosomal disorder called hereditary hemorrhagic telangiectasia (HHT), characterized with abnormal blood vessel formation (angiogenesis). As neutrophils are potent regulators of angiogenesis, we investigated how disturbed TGF-β/ALK1/ENG signaling influences angiogenic properties of these cells in HHT.
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