Publications by authors named "F Dome"
The goal of this article is to emphasize the role of anatomopathology for the intratumoral detection of the immune checkpoint PD-L1. This molecule is one of the main targets in the anti-cancer immunotherapy. The binding of PD-L1 to its receptor PD-1 results in the inactivation of the cytotoxic T-cells, thus providing a mechanism of keeping immune reactions under control.
View Article and Find Full Text PDFCystic adenomatoid malformations are part of localized malformations of lung tissue. They are characterized by the presence of cysts. The diagnosis is typically made during the second trimester of pregnancy.
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- Transbronchial lung cryobiopsies (TBLCs) have shown promise for diagnosing diffuse parenchymal lung diseases (DPLDs), but their effectiveness compared to surgical lung biopsies (SLBs) is still debated.
- A study was conducted on 81 patients who had TBLCs, with subsequent SLBs performed for uncertain diagnoses or if a nonspecific interstitial pneumonia (NSIP) pattern was observed, revealing that SLBs provided more specific histological diagnoses.
- The findings suggest that while TBLCs are valuable, SLBs are essential for obtaining critical additional diagnostic information when TBLCs yield inconclusive results or indicate an NSIP pattern, highlighting their importance in complex cases.
Non-specific Interstitial Pneumonia (NSIP) is an anatomo-clinical entity within the group of Diffuse Infiltrative Pulmonary Diseases (DPID). It is very rarely found in pediatrics. Main symptoms are dry cough and dyspnea.
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