A H@CH NMR probe for sensitively detecting the supramolecular interactions between a molecular tweezer and C.

Herein, we firstly utilized H@C to monitor the supramolecular interaction between a pH-driven resorcin[4]arene molecular tweezer and C with a notable H NMR chemical shift change ( 0.34 ppm). This work provides a new strategy for detecting weak or complex supramolecular interactions.

Smartphone-assisted training with education for patients with hip and/or knee osteoarthritis (SmArt-E): study protocol for a multicentre pragmatic randomized controlled trial.

Introduction: Hip and knee osteoarthritis are associated with functional limitations, pain and restrictions in quality of life and the ability to work. Furthermore, with growing prevalence, osteoarthritis is increasingly causing (in)direct costs. Guidelines recommend exercise therapy and education as primary treatment strategies.

Cultural traits and second-generation immigrants' value of informal care.

Unlabelled: Many European studies find that immigrants and the native population differ in their long-term care use. These differences have been attributed to immigrants' cultural preferences, among others. However, the cultural integration process of immigrants may result in a potential caregiving conflict between foreign-born immigrants' preferences for long-term care and their children's willingness to provide long-term care.

Cost-effectiveness of surgical treatment compared to medical treatment in patients with drug-refractory epilepsy: A systematic review.

Background And Purpose: Approximately 30% of epilepsy patients develop a drug-refractory epilepsy, that is, seizures cannot be controlled with antiepileptic drugs. Surgery has been evaluated as an effective but costly form of treatment. The aim of this systematic review is to synthesize the available evidence on the cost-effectiveness of surgical treatment compared to medical treatment for these patients.

F-NMR Unveils the Ligand-Induced Conformation of a Catalytically Inactive Twisted Homodimer of tRNA-Guanine Transglycosylase.

Understanding the structural arrangements of protein oligomers can support the design of ligands that interfere with their function in order to develop new therapeutic concepts for disease treatment. Recent crystallographic studies have elucidated a novel twisted and functionally inactive form of the homodimeric enzyme tRNA-guanine transglycosylase (TGT), a putative target in the fight against shigellosis. Active-site ligands have been identified that stimulate the rearrangement of one monomeric subunit by 130° against the other one to form an inactive twisted homodimer state.