Publications by authors named "F Di Dona"
Article Synopsis
- Enzyme replacement therapy (ERT) with velmanase alfa demonstrated effectiveness and safety for up to 12 years in patients with alpha-mannosidosis based on a pooled analysis from two multicenter trials.
- In pediatric patients, improvements in six-minute walk test (6MWT) and stair climb test (3MSCT) were observed, while adult patients showed stabilization or slight decline in performance.
- The treatment resulted in sustained clearance of serum oligosaccharides and increased serum immunoglobulin G (IgG) levels, with most adverse events being mild to moderate in severity, indicating that velmanase alfa is generally well-tolerated.
Article Synopsis
- Research found that exposure to glyphosate and glyphosate-based herbicides in female rats during pregnancy and lactation led to preimplantation losses and may affect gene transcription through epigenetic changes.* -
- The study involved treating mother rats with glyphosate or a glyphosate herbicide, then analyzing the offspring's uterine tissues for changes in gene expression, DNA methylation, and histone modifications.* -
- Results indicated that both glyphosate and its herbicide counterpart resulted in decreased gene expression, increased DNA methylation, and distinct histone modifications, suggesting their potential role in implantation failure.*
Glyphosate-based herbicides (GBHs) or its active ingredient, glyphosate (Gly), induce implantation failure in rats. We aimed to elucidate a mechanism of action of these compounds assessing the transcriptional and epigenetic status of the receptivity marker, leukemia inhibitory factor (Lif) gene. F0 rats were orally exposed to GBH or Gly at 3.
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- Gliosarcoma is a rare brain tumor in cats that has not been previously associated with changes in the hippocampus, but a case was reported involving a cat with complex partial seizures and orofacial symptoms.
- A 16-year-old cat showed symptoms like disorientation and ataxia, and MRI revealed a tumor in the right piriform lobe along with abnormalities in the hippocampus.
- Due to insufficient biomaterial, additional testing for associated conditions was not conducted, but the presence of gliosarcoma suggests that similar cases warrant MRI and antibody testing for proper diagnosis.
Exposure to glyphosate-based herbicides (GBH) and consumption of cafeteria (CAF) diet, which are widespread in Western society, seem to be associated with endometrial hyperplasia (EH). Here, we aimed to evaluate the effects of a subchronic low dose of GBH added to the CAF diet on the rat uterus. Female Wistar rats were fed from postnatal day (PND)21 until PND240 with chow (control) or CAF diet.
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