Publications by authors named "F Desseigne"
Article Synopsis
- A significant number of hereditary colorectal cancer (CRC) and colonic polyposis cases are not linked to known risk genes like MMR, APC, and MUTYH.
- New potential predisposition genes have been identified, with rare variants found in genes such as NTLH1, AXIN2, RNF43, BUB1, and TP53 in nine patients suspected of inherited CRC/polyposis.
- Seven of these variants were deemed pathogenic or likely pathogenic, suggesting they may account for up to 2.7% of inherited CRC cases and highlight the importance of genetic testing for better screening and counseling for affected families.
Background: The impact of adapted physical activity (APA) on health-related quality of life (HRQoL) in patients with advanced pancreatic ductal adenocarcinoma (aPDAC) is unknown. This study evaluated whether APA in addition to standard care improved HRQoL in patients who have aPDAC who are receiving first-line chemotherapy.
Patients And Methods: Patients with locally advanced/metastatic PDAC and an ECOG performance status of 0 to 2 were randomized (1:1) to receive standard care (standard arm) or standard care plus a home-based 16-week APA program (APA arm).
Article Synopsis
- The study aimed to evaluate the effectiveness of a preoperative chemoradiation (CRT) regimen in patients with gastric adenocarcinoma to improve surgical outcomes and response rates.
- In a phase II trial involving patients with stage IB to IIIC gastric adenocarcinoma, participants received a combination of chemotherapy and CRT before surgery, with a focus on measuring R0-resection rate and overall survival.
- Results showed high resection rates (78.8%) and promising survival statistics, suggesting that CRT could improve outcomes, although more extensive research through a phase III trial is recommended.
Gastric and esophageal adenocarcinomas represent a biologically heterogeneous disease. The identification, in early eighties, of human epidermal growth factor receptor 2 (HER2) overexpression, being present in 12 to 20% of the cases, marked a major milestone in the efforts of unraveling the molecular complexity of this disease. This led to the development of anti-HER2-therapies, trastuzumab being the first to demonstrate, in combination with cisplatin and 5FU/capecitabine chemotherapy, an improvement in response rate and survival in the first-line setting of patients with metastatic, HER2-positive gastroesophageal adenocarcinomas.
View Article and Find Full Text PDFThe POLD1 gene is involved in DNA proofreading to ensure accurate DNA replication. Some germline alterations in its exonuclease domain are associated with predisposition to cancers and colonic polyps. Only a few pathogenic variants have been clearly identified so far.
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