Publications by authors named "F Demailly"
A 50-year-old woman presented a dry syndrome, joint pain, inflammatory syndrome, polyclonal hypergammaglobulinemia, and tubulointerstitial nephritis. Imaging studies (including FDG PET/CT) revealed infrarenal retroperitoneal fibrosis with periaortitis and hypermetabolic osteosclerotic lesions. Bone scintigraphy demonstrated intense uptake in the femoral, tibial, and radial regions, suggestive of non-Langerhans histiocytosis, specifically Erdheim-Chester disease.
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- VEXAS syndrome is an adult-onset autoinflammatory disease caused by mutations in the UBA1 gene, first identified in 2020.
- Patients typically present symptoms of inflammatory syndromes like relapsing polychondritis or hematologic conditions like myelodysplastic syndrome.
- A case report describes a 70-year-old man with VEXAS syndrome showing a unique "leopard man" appearance on FDG PET/CT imaging, indicating abnormal bone marrow activity.
Objective: 18F-fluorodeoxyglucose PET/CT (FDG-PET/CT) is widely used in patients with large vessel vasculitis. The benefits of FDG-PET/CT in PAN has only ever been assessed in three case reports. Our aim was to describe FDG-PET/CT findings in 10 patients with newly diagnosed PAN.
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- Fatty acids are essential for maintaining membrane fluidity and are important for energy storage, particularly in freshwater diatoms like Gomphonema gracile, which were studied for their fatty acid profiles in response to pesticides.
- The research focused on the effects of the pesticides diuron and S-metolachlor, examining their impact on classical descriptors such as growth rate, photosynthesis, and gene expression over a seven-day exposure period.
- Findings revealed that S-metolachlor primarily affected growth and gene expression without altering fatty acid profiles, while diuron inhibited growth and photosynthesis but shifted fatty acid composition, highlighting how fatty acids could serve as indicators of energy content under herbicide stress.
Background: Brain metabolic profiles of patients with Parkinson's disease (PD) and cognitive impairment or dementia are now available. It would be useful if data on brain metabolism were also predictive of the risk of a pejorative cognitive evolution - especially in the multidisciplinary management of advanced PD patients.
Objective: The primary objective was to determine whether a specific brain metabolic pattern is associated with cognitive decline in PD.