Publications by authors named "F De Crescenzo"
Background: Antidepressants' effects are established in randomised controlled trials (RCTs), but not in the real world.
Aims: To investigate real-world comparative effects of antidepressants for depression and compare them with RCTs.
Method: We performed a cohort study based on the QResearch database.
Article Synopsis
- Pulmonary embolism (PE) after childbirth poses serious risks to both mothers and infants, requiring careful management.
- The case report highlights a patient with intermediate-high risk PE who experienced hemodynamic instability, complicating treatment.
- This situation emphasizes the need for updated clinical practices to effectively handle PE in post-partum patients.
Despite grey matter atrophy in cortical and subcortical regions has been related to cognitive impairment in multiple sclerosis, only a few studies evaluated its predictive value for alterations in the long-term. We aimed to determine early predictors of cognitive status after 20 years of multiple sclerosis. In this longitudinal retrospective study, participants underwent a 1.
View Article and Find Full Text PDFTumor necrosis factor (TNF) is a pleiotropic cytokine regulating many physiological and pathological immune-mediated processes. Specifically, it has been recognized as an essential pro-inflammatory cytokine implicated in multiple sclerosis (MS) pathogenesis and progression. MS is a chronic immune-mediated disease of the central nervous system, characterized by multifocal acute and chronic inflammatory demyelination in white and grey matter, along with neuroaxonal loss.
View Article and Find Full Text PDFBackground: New National Institute for Health and Care Excellence (NICE) guidance endorses the prescription of statins in larger population groups for the prevention of cardiovascular and cerebrovascular morbidity and mortality, especially in people with severe mental illness. However, the evidence base for their safety and risk/benefit balance in depression is not established.
Objectives: This study aims to assess the real-world mortality and adverse events of statins in depressive disorders.