Publications by authors named "F De Carne"
Background: The diagnostic process for prostate cancer after a negative biopsy is challenging. This study compares the diagnostic accuracy of micro-ultrasound (mUS) with multiparametric magnetic resonance imaging (mpMRI) for such cases.
Methods: A retrospective cohort study was performed, targeting men with previous negative biopsies and using mUS and mpMRI to detect prostate cancer and clinically significant prostate cancer (csPCa).
Objectives: To develop a microultrasound-based nomogram including clinicopathological parameters and microultrasound findings to predict the presence of extra-prostatic extension and guide the grade of nerve-sparing.
Material And Methods: All patients underwent microultrasound the day before robot-assisted radical prostatectomy. Variables significantly associated with extra-prostatic extension at univariable analysis were used to build the multivariable logistic model, and the regression coefficients were used to develop the nomogram.
Article Synopsis
- Scientists wanted to see how well two types of prostate cancer tests worked for men who had suspicious signs during exams and scans.
- They found that using microultrasound-targeted biopsy (microUSTBx) with systematic biopsy (SBx) found cancer just as well as another method called mpMRI with targeted biopsy (MTBx).
- This new method not only helped find cancer accurately but also prevented many unnecessary tests, making it a better choice for some patients.
Article Synopsis
- Active surveillance (AS) is a common approach for managing low-risk prostate cancer, but identifying candidates for AS is difficult; this study investigates the effectiveness of microultrasound (microUS) in conjunction with mpMRI for monitoring these patients.
- A total of 100 prostate cancer patients underwent TRUS with microUS and targeted biopsies, revealing that 34 patients were upgraded to more significant disease at confirmatory biopsies, highlighting microUS's role in identifying clinically relevant cancer.
- The findings indicate that both microUS and mpMRI are highly sensitive tools for detecting clinically significant prostate cancer, which could improve decision-making in the management of patients undergoing active surveillance.
Assessing the Role of High-resolution Microultrasound Among Naïve Patients with Negative Multiparametric Magnetic Resonance Imaging and a Persistently High Suspicion of Prostate Cancer.
Eur Urol Open Sci
January 2023
Background: Multiparametric magnetic resonance imaging (mpMRI) is an invaluable diagnostic tool in the decision-making for prostate biopsies (PBx). However, a non-negligible proportion of patients with negative MRI (nMRI) may still harbour prostate cancer (PCa).
Objective: To assess whether microultrasound (micro-US) can help in substratifying the presence of PCa and clinically significant PCa (csPCa; ie, any Gleason score ≥7 PCa) in patients with nMRI despite a persistently high clinical suspicion of PCa.