Publications by authors named "F Darrouzain"
Background: Hepatitis E virus (HEV) is a zoonotic virus transmitted by pig meat and responsible for chronic hepatitis E in immunocompromised patients. It has proved challenging to reproduce this disease in its natural reservoir. We therefore aimed to develop a pig model of chronic hepatitis E to improve the characterization of this disease.
View Article and Find Full Text PDFArticle Synopsis
- The treatment of AML with unfavorable cytogenetics remains difficult, prompting a study on the effects of fish oil emulsion (FO) combined with a specific chemotherapy regimen (3+7).
- Thirty patients participated, showing that FO increased EPA and DHA levels significantly, but it didn't affect the chemotherapy drugs' pharmacokinetics.
- The study found a complete response rate of 77%, similar to previous trials, indicating that adding FO to the treatment doesn't significantly improve outcomes for high-risk AML patients.
Background: Silver is used in various industrial applications, but also in confectioneries and for therapeutic use due to its antibiotic properties. Its toxicity is not well documented and most often only in the context of professional exposure.
Aim: Here we report two cases of high silver concentrations in biological samples in two women: the first patient presented grey marks around her cuticles, probably due to her consumption of silvered sweets and the second patient presented agranulocytosis and thrombocytopenia occurring within 24 h after the topical application of a cream containing sulfadiazine and silver to burns over a large surface area.
The poor diffusion of intravenous antibiotics in lung tissue makes nosocomial pneumonia challenging to treat, notably in critical patients under mechanical ventilation. The combination of ultrasound and microbubbles (USMB) is an emerging method for non-invasive and targeted enhancement of uptake of various drugs in several organs. This study aims to evaluate if USMB may increase amikacin concentration in condensed lung tissues in a mechanically ventilated rabbit model.
View Article and Find Full Text PDF