Background: The benefits of preoperative chemotherapy and radiation for esophageal carcinoma are under investigation. A pilot study was undertaken to determine if pathologic assessment of tumor regression correlated with disease free survival.
Methods: Ninety-three resected specimens from patients treated with cis-dichloro-diamino cisplatin and irradiation before surgery were examined on semiserial sections.
The authors describe a method for sampling and embedding of oesophagectomy specimens which permits the study of the entire oesophagus with a minimum number of sections. Good localization of the lesions is achieved, and the simplicity of this method (accordion fold) makes it suitable for routine use.
View Article and Find Full Text PDF