Publications by authors named "F Dagradi"
Background: Congenital long QT syndrome (LQTS) is characterized by delayed ventricular repolarization, predisposing to potentially lethal ventricular arrhythmias. The variability in disease severity among patients remains largely unexplored, underscoring the limitations of current risk stratification methods.
Objective: We aimed to evaluate the potential utility of electrocardiographic markers from the exercise stress test (EST) in identifying patients with high-risk LQTS.
Article Synopsis
- About 15% to 20% of long QT syndrome (LQTS) patients are genotype-negative (GEN-), leading to uncertainties in their risk and treatment compared to genotype-positive (GEN+) patients.
- The study evaluated 832 LQTS patients in Japan and Italy, finding that GEN- patients had more cardiac events and less family history of LQTS, especially in Japan.
- Despite some differences, the study concluded that the arrhythmic risk and clinical outcomes were similar for both GEN+ and GEN- patients, suggesting they should be managed the same way.
Article Synopsis
- Guideline-directed therapy for LQTS has changed, with varying ICD recommendations depending on cardiac societies.
- A study analyzed 2861 patients with LQT types to see who met the 2022 guidelines for ICDs and compared outcomes for those with and without an ICD.
- Results showed that while many patients met recommendations for ICDs, more than half did not receive one, and those without an ICD had significantly fewer cardiac events than those with one.
Background: Long QT syndrome is a lethal arrhythmia syndrome, frequently caused by rare loss-of-function variants in the potassium channel encoded by . Variant classification is difficult, often because of lack of functional data. Moreover, variant-based risk stratification is also complicated by heterogenous clinical data and incomplete penetrance.
View Article and Find Full Text PDFBackground: Young (<18 years of age) patients with Brugada syndrome (BrS) are often under-represented in BrS studies and their management, especially related to syncopal episodes, remains unclear.
Objectives: This study sought to describe the arrhythmia prevalence among young patients with BrS undergoing continuous rhythm monitoring by implantable loop recorder (ILR) and to assess the etiology behind syncope of undetermined origin.
Methods: A total of 147 patients with BrS with ILR were enrolled in 12 international centers and divided into pediatric (age <12 years; n = 77, 52%) and adolescents (age 13-18 years; n = 70, 48%).