Publications by authors named "F DELEO"
The interaction between basic science epilepsy researchers and clinical epileptologists is a longstanding issue. Efforts to provide opportunities for a dialogue between preclinical and clinical epilepsy professionals are crucial to reduce the knowledge gap between them and improve the translational success of neurobiology-based research. The International League Against Epilepsy (ILAE) Research and Innovation Task Force circulated a survey to investigate the need for an update on new clinical epilepsy concepts within the basic science community.
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- This case report emphasizes the need for comprehensive testing methods, including video-EEG, MEG, and MRI, to accurately diagnose negative motor seizures (NMSs) and differentiate them from other conditions.
- The study presents a 62-year-old patient with drug-resistant focal epilepsy and NMSs, highlighting the importance of monitoring that indicated specific brain activity and muscular responses during seizures.
- Findings from the multimodal evaluations revealed an epileptic zone in the right opercular region, associated with brain abnormalities, thereby improving our understanding of NMSs and their underlying brain mechanisms.
Article Synopsis
- The study investigates the use of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) to improve the diagnosis of focal cortical dysplasia (FCD) in epilepsy patients who haven't responded to medication.
- MALDI-MSI was applied to brain tissue samples from 10 FCD type IIb cases, revealing unique histopathological traits and allowing visualization of diagnostic markers directly within the tissue.
- This research aims to create a molecular signature library to better distinguish between tissue characteristics, potentially enhancing patient classification and outcomes after epilepsy surgery.
Unlabelled: is a leading cause of healthcare-associated infections globally. Vancomycin-resistant (VRSA), those with high-level resistance [minimum inhibitory concentration (MIC) of 16-32 µg/mL vancomycin], are uncommon, whereas vancomycin-intermediate (VISA; MIC of 4-8 µg/mL), are isolated more frequently and develop during long-term and/or repeated use of the antibiotic. VISA can be difficult to eradicate and infections may persist.
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