Publications by authors named "F D Lowy"
Background: Staphylococcus aureus skin and soft tissue infections (SA-SSTIs) are common in healthcare and community settings, and recurrences occur at variable frequency, even after successful initial treatment. Knowing the exact burden and timing of recurrent disease is critical to planning and evaluating interventions to prevent recurrent SSTIs.
Methods: In this retrospective study, SSTI cases in patients aged ≥18 years at 3 US medical centers (Columbia, Chicago, Vanderbilt) between 2006 and 2016 were analyzed according to a biennial cohort design.
The small messenger RNA (SmRNA) of the (ANDV), a rodent-borne member of the family of viruses of the order, encodes a multifunctional nucleocapsid (N) protein and for a nonstructural (NSs) protein of unknown function. We have previously shown the expression of the ANDV-NSs, but only in infected cell cultures. In this study, we extend our early findings by confirming the expression of the ANDV-NSs protein in the lungs of experimentally infected golden Syrian hamsters.
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- Antibiotic resistance, particularly from methicillin-resistant Staphylococcus aureus (MRSA), poses a serious threat to modern medicine by limiting treatment options.
- Research indicates that many MRSA strains can be treated effectively with penicillins combined with β-lactamase inhibitors like clavulanic acid, due to specific mutations that alter the bacteria's resistance.
- The study also reveals that using penicillin against certain MRSA strains can exploit their susceptibility, showing potential for previously overlooked antibiotics to remain effective in treating a significant number of MRSA infections.
Background: Understanding the changing epidemiology of Staphylococcus aureus bacteremia, as well as the variables associated with poor outcomes, can yield insight into potential interventions.
Methods: This study was a retrospective, observational cohort study of adult patients at an academic medical center in New York City who had S. aureus bloodstream infections between 1 January 2007 and 31 December 2015.