Publications by authors named "F D Kolodgie"
We evaluated a novel dual active pharmaceutical ingredient (API) drug-coated balloon (DCB), which consists of a coating of nanoparticles encapsulating low-dose paclitaxel (PTX) in combination with sirolimus in a synergistic ratio. Compared to the PTX DCB, the dual API DCB demonstrated similar inhibition of cell proliferation in vitro but at a significantly lower total drug dose (over 13 times lower than sirolimus nanoparticles). Animal experiments demonstrated that the dual API DCB is more effective in inhibiting intimal cell proliferation with insignificant downstream embolic effects and myocardial damage compared to the PTX DCB.
View Article and Find Full Text PDFBackground: Cell phenotype switching is increasingly being recognized in atherosclerosis. However, our understanding of the exact stimuli for such cellular transformations and their significance for human atherosclerosis is still evolving. Intraplaque hemorrhage is thought to be a major contributor to plaque progression in part by stimulating the influx of CD163 macrophages.
View Article and Find Full Text PDFBackground: During the transition from dual antiplatelet therapy (DAPT) to single antiplatelet therapy (SAPT), previous studies have raised concerns about a rebound effect. We compared platelet and inflammatory cell adhesion on different types of stents in the setting of clopidogrel presence and withdrawal.
Methods: In Experiment 1, three pigs were administered with DAPT, that is, clopidogrel and acetylsalicylic acid (ASA), for 7 days.
Polygenic Risk Score Associates With Atherosclerotic Plaque Characteristics at Autopsy.
Arterioscler Thromb Vasc Biol
January 2024
Article Synopsis
- Polygenic risk scores (PRSs) can enhance predictions of coronary artery disease (CAD) risk, and this study investigates their link to histopathologic features of CAD based on autopsy data from 4327 sudden death cases.
- The analysis involved 954 participants, revealing that those with the highest PRS quintile exhibited significantly worse atherosclerosis characteristics, such as higher %stenosis and greater calcification rates, even when accounting for traditional risk factors.
- The study concludes that individuals in the highest PRS quintile are at a markedly increased risk of severe atherosclerosis and CAD-related death, especially in those aged 50 and below.
Article Synopsis
- A study was conducted to evaluate the relationship between polygenic risk scores (PRS) for coronary artery disease (CAD) and the severity of atherosclerosis in subjects who died suddenly.
- From over 4,300 subjects, 954 cases were analyzed, revealing that those in the highest PRS quintile exhibited more severe atherosclerosis and higher rates of critical plaque features compared to those in the lowest quintile.
- The findings suggest that higher PRS is linked to increased odds of severe atherosclerosis and CAD-related deaths, particularly in younger individuals, marking a significant advancement in understanding CAD risk factors.