The IL-2 SYNTHORIN molecule promotes functionally adapted Tregs in a preclinical model of type 1 diabetes.

Deficits in IL-2 signaling can precipitate autoimmunity by altering the function and survival of FoxP3+ regulatory T cells (Tregs) while high concentrations of IL-2 fuel inflammatory responses. Recently, we showed that the non-beta IL-2 SYNTHORIN molecule SAR444336 (SAR'336) can bypass the induction of autoimmune and inflammatory responses by increasing its reliance on IL-2 receptor α chain subunit (CD25) to provide a bona fide IL-2 signal selectively to Tregs, making it an attractive approach for the control of autoimmunity. In this report, we further demonstrate that SAR'336 can support non-beta IL-2 signaling in murine Tregs and limit NK and CD8+ T cells' proliferation and function.

Precise Mechanical Oscillator Design and Calibration for Characterising Sub-Millimetre Movements in mmWave Radar Systems.

For many industrial and medical applications, measuring sub-millimetre movements has become crucial, for instance, for the precise guidance of surgical robots. The literature shows the feasibility of millimetre-wave (mmWave) radars to deal with such micro-vibrations. However, the availability of reference devices to configure and test these systems is very limited.

Xoconochcothelphusa, a new genus for Ehecatusa chiapensis (Rodríguez & Smalley, 1972), with notes on Spirothelphusa Pretzmann, 1965 (Crustacea: Decapoda: Pseudothelphusidae).

The species of the genus Ehecatusa Ng & Low, 2010, E. chiapensis (Rodríguez & Smalley, 1972) and E. mixtepensis (Rodríguez & Smalley, in Smalley, 1970), were referred to as incertae sedis in the classification system of the tribe Pseudothelphusini Ortmann, 1897, proposed by Villalobos-Hiriart (2005) and Villalobos & Alvarez(2010) and as members of the subfamily Pseudothelphusinae in the recent phylogenetic proposal by Álvarez et al.

Visible Light-Driven Photocatalysis and Antibacterial Performance of a Cu-TiO Nanocomposite.

A Cu-TiO nanomaterial with unique antibacterial and photocatalytic properties is introduced in this study. Cu-TiO nanocomposites were obtained using an adapted direct current magnetron sputtering apparatus, where TiO anatase nanoparticles (NPs) were used as the substrates and copper as the sputtering target. The obtained powder was characterized by physical and chemical methods.