Publications by authors named "F D'Este"

Plant phenotyping on morpho-anatomical traits through image analysis, from microscope images to large-scale acquisitions through remote sensing, represents a low-invasive tool providing insight into physiological and structural trait variation, as well as plant-environment interactions. High phenotype diversity in the genus Amaranthus includes annual weed species with high invasiveness and impact on important summer crops, and nutritive grain or vegetable crops. Identification of morpho-anatomical leaf characters at very young stages across weedy amaranths could be useful for better understanding their performance in agroecosystems.

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Placental insufficiency often correlates with fetal growth restriction (FGR), a condition that has both short- and long-term effects on the health of the newborn. In our study, we analyzed placental tissue from infants with FGR and from infants classified as small for gestational age (SGA) or appropriate for gestational age (AGA), performing comprehensive analyses that included transcriptomics and metabolomics. By examining villus tissue biopsies and 3D trophoblast organoids, we identified significant metabolic changes in placentas associated with FGR.

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Access to DNA is the first level of control in regulating gene transcription, a control that is also critical for maintaining DNA integrity. Cellular senescence is characterized by profound transcriptional rearrangements and accumulation of DNA lesions. Here, we discovered an epigenetic complex between HDAC4 and HDAC1/HDAC2 that is involved in the erase of H2BK120 acetylation.

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In pancreatic ductal adenocarcinomas (PDAC), the axis controls cellular functions such as redox homeostasis and metabolism. Disruption of this axis through suppression of leads to profound reprogramming of metabolism. Unbiased transcriptome and metabolome analyses showed that PDAC cells with disrupted signaling ( cells) shift from aerobic glycolysis to metabolic pathways fed by amino acids.

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The need to minimise the impact of phytosanitary treatments for disease control boosted researchers to implement techniques with less environmental impact. The development of technologies using molecular mechanisms based on the modulation of metabolism by short dsRNA sequences appears promising. The intrinsic fragility of polynucleotides and the high cost of these techniques can be circumvented by nanocarriers that protect the bioactive molecule enabling high efficiency delivery to the leaf surface and extending its half-life.

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