Publications by authors named "F D'Auria"
Background: The other side of radiotherapy (RT), in addition to the cytotoxic effect, is the ability to modulate the immune system in terms of activation or suppression, also depending on the dose and fractionation delivered. This immune RT effect can be detected both locally in the irradiated tumor site and in the peripheral blood. The aim of this study was to assess the consequence of pelvic irradiation on peripheral immune cells and cytokine secretions in localized prostate cancer (PC) patients undergoing pelvic irradiation with a simultaneous moderately hypofractionated prostate/prostate bed boost by Volumetric Modulated Arc Therapy (VMAT).
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- Lymphoproliferative diseases involve various types of malignant lymphocyte growth, making diagnosis challenging due to their diverse presentations and characteristics.
- Flow cytometry has emerged as a valuable tool for diagnosing T-cell disorders, particularly when the number of cancerous cells is low.
- A case study of a 55-year-old man with two distinct T-cell clones highlights the importance of accurate diagnostic methods, as the patient's quick decline prevented a conclusive identification of one of the clones.
Article Synopsis
- - Atypical chronic lymphocytic leukemia (CLL) is diagnosed based on shape and structure, but deviations from the usual immune profile indicate a need to look for atypical cases.
- - In a study comparing atypical and typical CLL cases, atypical presentations showed distinct immune marker expressions, including higher CD20 and unmutated IgVH rates, and were associated with more advanced disease stages.
- - While morphological features seem to provide better insights into patient prognosis, the effectiveness of using both morphology and immunophenotype in guiding treatment decisions remains uncertain and requires additional research.
Article Synopsis
- The Italian Society of Echography and Cardiovascular Imaging (SIECVI) conducted a national survey to investigate stress echocardiography (SE) practices across Italy, collecting data from 228 laboratories in November 2022.
- The survey revealed that out of 179 centers performing SE, most were located in northern Italy, and the study categorized them into low, moderate, and high volume of activity based on the number of SE examinations.
- Key findings indicated differences in the use of stressors, with a tendency for high-volume centers to employ multiple stress techniques and incorporate advanced evaluations like coronary flow velocity reserve (CFVR) more frequently than low and moderate volume centers.