Publications by authors named "F D'Aniello"
Context: Congenital hypogonadotropic hypogonadism (CHH) is defined as an isolated deficiency of gonadotropin hormones. Mini-puberty, a transient postnatal activation of the hypothalamic-pituitary-gonadal axis in healthy infants, provides a window of opportunity to diagnose and treat CHH. Currently, in male infants with CHH, testosterone is used to increase phallus size.
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- Precocious puberty occurs when secondary sexual traits appear before age 8 in girls and 9 in boys, with central precocious puberty (CPP) being a rare type linked to early hormonal activation.
- A new case of an 8-year-old girl showed a specific genetic change in the DLK1 gene, leading to advanced puberty and related health issues like obesity and insulin problems.
- The findings emphasize the need for ongoing health monitoring in children with DLK1 mutations, highlighting a trend of metabolic issues such as obesity and irregular cholesterol levels in affected individuals.
Introduction: Growth patterns in Noonan syndrome (NS) remain relatively unknown. The objective of this study was to provide growth reference curves for patients with NS and identify correlations between their growth, genotype, and clinical features.
Methods: This was a 15-year-long, monocentric, observational, retrospective, non-interventional study.
Purpose: In light of the growing concern over the possible link between SARS-CoV2 infection and autoimmune diseases, we conducted a review to investigate the impact of the pandemic outbreak on thyroid diseases.
Methods: We carried out a narrative review of all pediatric cases described in the literature, mainly focusing on the possible association of COVID-19 with the incidence of autoimmune and post-infective thyroid diseases (namely Hashimoto's Thyroiditis (HT), Grave's Disease (GD) and Sub-Acute Thyroiditis (SAT)). We also felt it was necessary to provide a brief review of Non-thyroidal Illness Syndrome (NTIS) and Multisystem Inflammatory Syndrome in Children (MIS-C) because of their overlap with thyroiditis.
Purpose: Tall stature is defined as height greater than the threshold of more than 2 standard deviations above the average population height for age, sex, and ethnicity. Many studies have described the main aspects of this condition during puberty, but an analysis of the characteristics that the physician should consider in the differential diagnosis of gigantism-tall stature secondary to a pituitary tumour-during the transition age (15-25 years) is still lacking.
Methods: A comprehensive search of English-language original articles was conducted in the MEDLINE database (December 2021-March 2022).